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首页> 外文期刊>Spine >Anti-Nociceptive Effect of Bovine Milk-Derived Lactoferrin in a Rat Lumbar Disc Herniation Model
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Anti-Nociceptive Effect of Bovine Milk-Derived Lactoferrin in a Rat Lumbar Disc Herniation Model

机译：牛乳来源的乳铁蛋白在大鼠腰椎间盘突出症模型中的抗伤害感受作用

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Study Design. An experimental animal study.Objective. We evaluated the efficacy of lactoferrin (LF) compared with diclofenac to reduce the pain, using a rat lumbar disc herniation model.Summary of Background Data. LF is a multifunctional protein that is found in milk. Recent studies have reported that LF reduces nociception in various experimental models.Methods. Rats were operated on the left L5 vertebral arch. The left L5 nerve root and dorsal root ganglion (DRG) were exposed by a L5 partial laminectomy. An L-shaped stainless steel rod was inserted from the laminectomy toward the intervertebral foramen to compress the nerve root. In addition, nucleus pulposus from coccy-geal discs was applied on the nerve root. At 1 day before operation, all rats were tested regarding the withdrawal threshold of the left plantar surface using von Frey filaments to determine baseline values. Additional von Frey tests were performed on postoperative days 3, 7,14, and 21. Thirty minutes before each test except for baseline, the rats received LF (100 mg/kg), diclofenac (10 mg/kg), or saline by intraperitoneal injection (n = 6).
机译：学习规划。实验动物研究。我们使用大鼠腰椎间盘突出症模型评估了乳铁蛋白（LF）与双氯芬酸相比在减轻疼痛方面的功效。背景数据摘要。 LF是牛奶中发现的一种多功能蛋白质。最近的研究报道了LF在各种实验模型中均降低了伤害感受。大鼠在左L5椎弓根上手术。通过L5部分椎板切除术暴露左L5神经根和背根神经节（DRG）。从椎板切除术向椎间孔插入L形不锈钢棒以压迫神经根。另外，将来自尾骨-圆盘的髓核涂在神经根上。在手术前1天，使用von Frey细丝测试所有大鼠的左足底表面缩回阈值，以确定基线值。术后第3、7、14和21天进行了额外的von Frey测试。除基线外，每项测试前30分钟，大鼠腹腔注射LF（100 mg / kg），双氯芬酸（10 mg / kg）或盐水注射（n = 6）。

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