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首页> 外文期刊>Spine >A clinical comparative study on low versus medium viscosity PolyMethylMetAcrylate bone cement in percutaneous Vertebroplasty: viscosity associated with cement leakage.
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A clinical comparative study on low versus medium viscosity PolyMethylMetAcrylate bone cement in percutaneous Vertebroplasty: viscosity associated with cement leakage.

机译:中低粘度聚甲基丙烯酸甲酯骨水泥在经皮椎体成形术中的临床比较研究:与水泥渗漏有关的粘度。

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摘要

STUDY DESIGN: Comparative, prospective follow-up study. OBJECTIVE: Comparison of outcome between patients treated with Percutaneous VertebroPlasty (PVP) using low and medium viscosity PolyMethylMetAcrylate (PMMA) bone cement. SUMMARY OF BACKGROUND DATA: Viscosity is the characterizing parameter of PMMA bone cement, currently the standard augmentation material in PVP, and influences interdigitation, cement distribution inside the vertebral body, injected volume and extravasation, thereby affecting the clinical outcome of PVP. Currently, low, medium, and high viscosity PMMA bone cements are used interchangeably. However, effect of viscosity on clinical outcome in patients with Osteoporotic Vertebral Compression Fractures (OVCFs) has not yet been explicit subject of investigation. METHODS: Follow-up was conducted using a 0 to 10 Pain Intensity Numerical Rating Scale (PI-NRS) and the Short Form 36 (SF-36) Quality of Life questionnaire before PVP and at 7 days (PI-NRS only), 1, 3, and 12 months after PVP. Injected cement volume, degree of interdigitation, and cement leakage were analyzed on direct postoperative computed tomography scanning. At 6 and 52 weeks and at suspicion, patients were analyzed for new fractures. RESULTS: A total of 30 consecutive patients received PVP using low viscosity PMMA bone cement (OsteoPal-V) for 62 OVCFs, followed by 34 patients who received PVP using medium viscosity PMMA bone cement (Disc-O-Tech) for 67 OVCFs. Results regarding PI-NRS and SF-36 were comparable between both groups. Postoperative comparison of injected cement volume, degree of interdigitation, proportion of bipedicular procedures, incidence of new vertebral fractures and complications revealed no differences between both groups. Viscosity was identified as a risk factor for the occurrence of cement leakage (yeso, OR: 2.925, 95% confidence interval: [1.072-7.984], P = 0.036). CONCLUSION: No major differences in clinical outcome after PVP in OVCFs using low and medium viscosity PMMA bone cement were found. Viscosity of PMMA bone cement was identified as an independent predictor of cement leakage.
机译:研究设计:比较性,前瞻性随访研究。目的:比较使用中低粘度聚甲基丙烯酸甲酯(PMMA)骨水泥经皮椎体成形术(PVP)治疗的患者的结局。背景数据摘要:粘度是PMMA骨水泥(目前是PVP中的标准增强材料)的表征参数,并影响交叉指,椎骨内的水泥分布,注射量和外渗,从而影响PVP的临床结果。当前,低,中和高粘度的PMMA骨水泥可互换使用。然而,粘度对骨质疏松性椎体压缩性骨折(OVCF)患者临床结局的影响尚未成为明确的研究对象。方法:随访采用0-10疼痛强度数值评分量表(PI-NRS)和简短表格36(SF-36)生活质量问卷进行,PVP之前和第7天(仅PI-NRS),1 PVP后3个月和12个月。术后直接进行计算机体层摄影扫描分析注入的水泥量,交叉指骨度和水泥渗漏。在怀疑的第6周和第52周,对患者进行了新的骨折分析。结果:共有30例连续患者接受62 OVCF的低粘度PMMA骨水泥(OsteoPal-V)接受PVP,随后34例接受67 OVCF的中粘度PMMA骨水泥(Disc-O-Tech)接受PVP。两组之间关于PI-NRS和SF-36的结果相当。术后比较注射的骨水泥量,交叉度,双足手术比例,新椎骨骨折的发生率和并发症,发现两组之间无差异。粘度被确定为发生水泥渗漏的危险因素(是/否,或:2.925,95%置信区间:[1.072-7.984],P = 0.036)。结论:在使用中低粘度PMMA骨水泥的OVCF中,PVP后的临床结局无重大差异。 PMMA骨水泥的粘度被确定为水泥渗漏的独立预测因子。

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