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首页> 外文期刊>Biomaterials >EFFECTS OF ALKALINE PHOSPHATASE ON BONE HEALING AROUND PLASMA-SPRAYED TITANIUM IMPLANTS - A PILOT STUDY IN RABBITS
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EFFECTS OF ALKALINE PHOSPHATASE ON BONE HEALING AROUND PLASMA-SPRAYED TITANIUM IMPLANTS - A PILOT STUDY IN RABBITS

机译：碱性磷酸酶对等离子喷涂钛植入物骨愈合的影响-兔的初步研究

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摘要

Alkaline phosphatase (ALP) is an enzyme thought to be important in the process of biomineralization. ALP promotes hydrolysis of phosphate containing substrates, produces orthophosphate and increases the uptake of calcium. ALP has been demonstrated recently to induce mineralization of collagen sheets in the animal body. Many factors are being investigated to try to increase the quantity of bone around dental implants. The aim of this study was an evaluation of the bone formation around dental implants used in conjunction with ALP extracted from calf intestine. Titanium plasma-sprayed implants were put for 30 min in glasses containing 500 mu g of ALP, and then inserted into the femoral articular surface of the knee joint. The implants were retrieved after 2, 3, 4 and 8 weeks, and treated to obtain thin ground sections. The histological examination showed a higher quantity of bone trabeculae, and at 2 and 3 weeks, the presence of plump, elongated, highly stained, very active ALP-positive osteoblasts around the treated specimens. ALP seems, in the experimental conditions of this pilot study, to have a positive effect on bone formation around titanium plasma-sprayed implants. (C) 1996 Elsevier Science Limited [References: 25]
机译：碱性磷酸酶（ALP）是一种被认为在生物矿化过程中很重要的酶。 ALP促进含磷酸盐的底物的水解，产生正磷酸盐并增加钙的吸收。最近已经证明了ALP诱导动物体内胶原片的矿化。人们正在研究许多因素以尝试增加牙科植入物周围的骨骼数量。这项研究的目的是评估与从小牛肠中提取的ALP结合使用的牙科植入物周围的骨形成。将钛等离子喷涂的植入物放入含有500μg ALP的玻璃杯中放置30分钟，然后插入到膝关节的股骨关节表面。在2、3、4和8周后取回植入物，并进行处理以获得较薄的地面部分。组织学检查显示较高的骨小梁数量，在第2和3周时，在处理过的标本周围存在丰满的，细长的，高度染色的，非常活跃的ALP阳性成骨细胞。在该初步研究的实验条件下，ALP似乎对钛等离子喷涂植入物周围的骨形成具有积极作用。 （C）1996 Elsevier Science Limited [参考：25]

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