• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Stem Cells >Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens.
【24h】

Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens.

机译：植入前的人类胚胎和胚胎干细胞显示出阶段特异性胚胎抗原的可比表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cell-surface antigens provide invaluable tools for the identification of cells and for the analysis of cell differentiation. In particular, stage-specific embryonic antigens that are developmentally regulated during early embryogenesis are widely used as markers to monitor the differentiation of both mouse and human embryonic stem (ES) cells and their malignant counterparts, embryonic carcinoma (EC) cells. However, there are notable differences in the expression patterns of some such markers between human and mouse ES/EC cells, and hitherto it has been unclear whether this indicates significant differences between human and mouse embryos, or whether ES/EC cells correspond to distinct cell types within the early embryos of each species. We now show that human ES cells are characterized by the expression of the cell-surface antigens, SSEA3, SSEA4, TRA-1-60, and TRA-1-81, and by the lack of SSEA1, and that inner cell mass cells of the human blastocyst express a similar antigen profile, in contrast to the corresponding cells of the mouse embryo.
机译：细胞表面抗原为细胞鉴定和细胞分化分析提供了宝贵的工具。特别是，在胚胎早期发育过程中受到发育调控的阶段特异性胚胎抗原被广泛用作监测小鼠和人类胚胎干（ES）细胞及其恶性对应物胚胎癌细胞（EC）分化的标记。然而，人和小鼠ES / EC细胞之间某些标记的表达模式存在显着差异，到目前为止，尚不清楚这是否表明人胚胎和小鼠胚胎之间存在显着差异，或者ES / EC细胞是否对应于不同的细胞每个物种的早期胚胎中的类型。我们现在显示，人类ES细胞的特征在于细胞表面抗原，SSEA3，SSEA4，TRA-1-60和TRA-1-81的表达，以及缺少SSEA1的特征，以及与小鼠胚胎的相应细胞相比，人胚泡表达相似的抗原谱。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号