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首页> 外文期刊>Stereotactic and Functional Neurosurgery: Official Journal of the World Society for Stereotactic and Functional Neurosurgery >A retrospective analysis of tumor volumetric responses to five-fraction stereotactic radiotherapy for paragangliomas of the head and neck (Glomus tumors)
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A retrospective analysis of tumor volumetric responses to five-fraction stereotactic radiotherapy for paragangliomas of the head and neck (Glomus tumors)

机译：回顾性分析头颈部神经节瘤对五次立体定向放疗的肿瘤体积反应（Glomus肿瘤）

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Background: Skull base paragangliomas (SBP) are locally expansile tumors that can be treated with stereotactic radiotherapy with favorable results. This report describes the results of 31 patients with SBP treated with CyberKnife radiotherapy delivering a total dose of 25 Gray in five fractions. Methods: All patients treated with five-fraction CyberKnife radiotherapy at a single institution were identified between 2007 and 2013. Tumor volumetric analyses were performed to assess responses to radiotherapy. Results: Median follow-up was 24 months with a range of 4-78 months. Local control and overall survival were 100%. Of the 20 patients who presented with tinnitus, 12 reported improvement (60%), of whom 6 reported complete resolution. There was a 37.3% reduction in tumor volume among all patients (p = 0.16). On subset analysis of patients with ≥24 months of follow-up, tumor volume decreased 49% (p = 0.01). The rate of grade 1-2 toxicity was 19%, with no grade 3 or worse toxicity. Conclusion: A five-fraction CyberKnife-based stereotactic radiotherapy approach is safe and efficacious for the management for patients with SBP. Our findings suggest the potential use of this strategy as a definitive or salvage treatment option for SBP.
机译：背景：颅底神经节瘤（SBP）是局部可扩张的肿瘤，可以通过立体定向放射疗法进行治疗，效果良好。该报告描述了用射波刀放射疗法治疗的31例SBP患者的结果，分五个剂量共提供25格雷剂量。方法：确定2007年至2013年在同一机构接受五次射波刀放射治疗的所有患者。进行肿瘤体积分析以评估对放射治疗的反应。结果：中位随访时间为24个月，范围为4-78个月。局部控制和总体生存率为100％。在出现耳鸣的20例患者中，有12例报告好转（60％），其中6例报告完全消退。所有患者的肿瘤体积减少了37.3％（p = 0.16）。在随访≥24个月的患者的子集分析中，肿瘤体积减少了49％（p = 0.01）。 1-2级毒性反应的发生率为19％，无3级或更严重的毒性反应。结论：基于电子刀的五级立体定向放射治疗方法对于SBP患者的治疗是安全有效的。我们的发现表明，该策略可作为SBP的确定性或挽救性治疗方案。

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