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首页> 外文期刊>Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy >Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations
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Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations

机译：分光光度法测定其制剂中盐酸哌唑乙酯，右美沙芬HBr和屈维汀的含量

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摘要

A simple, accurate and highly sensitive spectrophotometric method is proposed for the rapid determination of pipazethate hydrochloride, dextromethorphan hydrobromide and drotaverine hydrochloride using chromotrope 2B (C2B) and chromotrope 2R (C2R). The method consists of extracting the formed ion-associates into chloroform in the case of pipazethate HCl and dextromethorphan HBr or into methylene chloride in the case of drotaverine HCl. The ion-associates exhibit absorption maxima at 528, 540 and 532 nm with C2B and at 526, 517 and 522 nm with C2R for pipazethate HCl, dextromethorphan HBr and drotaverine HCl, respectively. The calibration curves resulting from the measurements of absorbance-concentration relations (at the optimum reaction conditions) of the extracted ion-pairs are linear over the concentration range 4.36-52.32 mu g mL(-1) for pipazethate, 3.7-48.15 mu g mL(-1) for dextromethorphan and 4.34-60.76 mu g mL(-1) for drotaverine, respectively. The effect of acidity, reagent concentration, time, solvent and stoichiometric ratio of the ion-associates were estimated. The molar absorptivity and Sandell sensitivity of the reaction products were calculated. Statistical treatment of the results reflects that the procedure is precise, accurate and easily applied for the determination of the drugs under investigation in pure form and in their pharmaceutical preparations. (c) 2006 Elsevier B.V. All rights reserved.
机译：提出了一种简单，准确，高灵敏的分光光度法，用于使用色谱2B（C2B）和色谱2R（C2R）来快速测定盐酸哌帕西乙酯，氢溴酸右美沙芬和盐酸屈花碱。该方法包括将形成的离子缔合物在盐酸哌唑乙酯和右美沙芬HBr中萃取到氯仿中，在盐酸屈曲维林中萃取到二氯甲烷中。离子缔合体对哌唑乙酸酯HCl，右美沙芬HBr和drotaverine HCl分别在528、540和532 nm处以及在C2R分别在526、517和522 nm处显示最大吸收。提取的离子对的吸光度-浓度关系（在最佳反应条件下）的测量结果得出的校准曲线在浓度范围为4.36-52.32μg mL（-1）的哌唑乙酸酯，3.7-48.15μg mL中呈线性（-1）对于右美沙芬和4.34-60.76μg mL（-1）对于屈他维林。估计了酸度，试剂浓度，时间，溶剂和离子缔合体化学计量比的影响。计算反应产物的摩尔吸光度和Sandell敏感性。结果的统计处理表明，该程序准确，准确且易于用于确定所研究药物的纯形式及其药物制剂。 （c）2006 Elsevier B.V.保留所有权利。

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