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首页> 外文期刊>Strahlentherapie und Onkologie >Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer : An Open-Label Comparative Cohort Trial.
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Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer : An Open-Label Comparative Cohort Trial.

机译：在原发性或复发性局部晚期胰腺癌中局部热疗联合放化疗：一项开放标签比较队列试验。

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PURPOSE: To evaluate the therapeutic effect of delivering regional hyperthermia (HT) plus chemoradiotherapy (CRT) in patients suffering from locally advanced unresectable pancreatic cancer (LAPC). METHODS: Between January 2000 and December 2008, 68 patients affected by primary (56/68) or recurrent (12/68) LAPC were treated either with CRT alone or CRT plus HT. Radiotherapy (RT) consisted of 3D conformal irradiation of tumor and regional lymph nodes (dose ranged from 30 Gy/10 fractions to 66 Gy/33 fractions). Chemotherapy (CT) consisted of gemcitabine (GEM) alone or in association with either oxaliplatin, cisplatin, or 5-FU. HT was delivered twice a week, concomitant with RT. RESULTS: In the current study, 60 of the original 68 patients were included. Median overall survival (OS) was 15 months in the HT group versus 11 months in the control group (log-rank test: p = 0.025). HT did not increase CRT toxicity. CONCLUSION: HT can be added safely to CRT in LAPC, thus, resulting in slightly prolonged survival in certain cases.
机译：目的：评估局部热疗（HT）和放化疗（CRT）对局部晚期不可切除的胰腺癌（LAPC）患者的治疗效果。方法：自2000年1月至2008年12月，对68例原发性（56/68）或复发性（12/68）LAPC患者进行了单独CRT或CRT加HT治疗。放射疗法（RT）包括肿瘤和局部淋巴结的3D保形照射（剂量范围从30 Gy / 10馏分到66 Gy / 33馏分）。化学疗法（CT）由单独的吉西他滨（GEM）或与奥沙利铂，顺铂或5-FU联合使用组成。 HT每周两次，与RT并存。结果：在本研究中，最初的68位患者中有60位被纳入研究。 HT组中位总生存期（OS）为15个月，而对照组为11个月（对数秩检验：p = 0.025）。 HT没有增加CRT毒性。结论：HT可以安全地添加到LAPC的CRT中，因此，在某些情况下可以稍微延长生存期。

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