...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Spectroscopy Letters >Simultaneous Determination of Seven Sulfonylurea-Type Oral Anti-Diabetic Agents in Adulterated Dietary Supplements and Traditional Chinese Medicines by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry
【24h】

Simultaneous Determination of Seven Sulfonylurea-Type Oral Anti-Diabetic Agents in Adulterated Dietary Supplements and Traditional Chinese Medicines by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry

机译：超高效液相色谱-串联质谱法同时测定掺假膳食补充剂和中药中的七种磺脲类口服抗糖尿病药

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

An ultraperformance liquid chromatography-tandem mass spectrometry method was developed for simultaneous determination of seven sulfonylurea-type oral anti-diabetic agents (glipizide, tolbutamide, tolazamide, gliclazide, glibenclamide, glimepiride, and glurenor) in dietary supplements and traditional Chinese medicines. The samples were extracted twice with methanol by ultrasound. The separation was achieved on a C18 column with the mobile phase consisting of acetonitrile and water (0.2% formic acid (v/v) and 5mM ammonium acetate), at a flow rate of 0.3mL/min with gradient elution. The analysis time was 8min per sample. The proposed method was validated for linearity (r>0.99), precision (relative standard deviation better than 6.0%), recoveries (83-110%), and the limit of detection in the range 0.3-2 mu gkg(-1). The proposed method is rapid, reliable, sensitive, accurate, and good applicability, and it was successfully applied to analyze 20 real samples of 15 dietary supplements and five traditional Chinese medicines.
机译：开发了一种超高效液相色谱-串联质谱法，用于同时测定膳食补充剂和中药中的7种磺酰脲类口服降糖药（格列吡嗪，甲苯磺丁脲，托拉唑胺，格列齐特，格列本脲，格列美脲和格列脲）。样品用甲醇通过超声波提取两次。在C18色谱柱上进行分离，流动相由乙腈和水（0.2％甲酸（v / v）和5mM乙酸铵）组成，流速为0.3mL / min，并进行梯度洗脱。每个样品的分析时间为8分钟。该方法的线性（r> 0.99），精密度（相对标准偏差优于6.0％），回收率（83-110％）以及检出限在0.3-2μgkg（-1）范围内均得到验证。该方法快速，可靠，灵敏，准确，适用性强，已成功用于分析15种膳食补充剂和5种中药的20种真实样品。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号