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首页> 外文期刊>Stroke: A Journal of Cerebral Circulation >Do different metabolic syndrome definitions predict cerebrovascular events and coronary heart disease independent of their components?: 9 years follow-up of the tehran lipid and glucose study
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Do different metabolic syndrome definitions predict cerebrovascular events and coronary heart disease independent of their components?: 9 years follow-up of the tehran lipid and glucose study

机译：不同的代谢综合征定义是否会独立于其成分预测脑血管事件和冠心病？：德黑兰血脂和葡萄糖研究的9年随访

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Background and Purpose-: The purpose of this study was to examine whether metabolic syndrome (MetS), applying different definitions, predicts incident coronary heart disease (CHD) and cerebrovascular events (CVAs) independent of its components. Methods-: Among 2548, aged ≥50 years, World Health Organization, International Diabetes Federation, and Joint Interim Statement criteria were used to define MetS. Cox proportional hazards regression was implemented to estimate hazard ratios of incident CVA and CHD. Results-: During 9.3 years of follow-up, 72 and 343 cases of CVA and CHD events occurred. The multivariate hazard ratios (95% CI) of incident CVA and CHD were 2.71 (1.57-4.68) and 2.07 (1.63-2.64) for MetS as defined by the Joint Interim Statement, respectively. There was no difference among the 3 definitions of MetS regarding the prediction of the CVA incidence. However, MetS as defined by the Joint Interim Statement predicted CHD better than the International Diabetes Federation definition. After adjustment for components, MetS lost its association with CHD and CVA; in this model, the elevated blood pressure and high fasting plasma glucose (International Diabetes Federation definition) showed significant risk for CVA events; regarding CHD events, the elevated blood pressure, high fasting plasma glucose, and, for World Health Organization definition, obesity and dyslipidemia remained as predictors. Conclusions-: All definitions of MetS were associated with CVA and CHD events. After adjusting its components, MetS lost its association with incident CVA and CHD; however, elevated blood pressure for both CVA and CHD events and high fasting plasma glucose for CHD events remained as independent predictors in all definitions.
机译：背景和目的-：这项研究的目的是检查代谢综合征（MetS）是否使用不同的定义来预测独立于其成分的冠心病（CHD）和脑血管事件（CVA）。方法：在2548名年龄≥50岁的人群中，世界卫生组织，国际糖尿病联合会和联合临时声明标准用于定义MetS。进行Cox比例风险回归以估计CVA和CHD事件的风险比。结果：在9.3年的随访期间，发生了72例和343例CVA和CHD事件。根据联合临时声明的定义，MetS的事件CVA和CHD的多元危险比（95％CI）分别为2.71（1.57-4.68）和2.07（1.63-2.64）。关于CVA发生率的预测，在MetS的3种定义之间没有差异。但是，联合临时声明中定义的MetS预测的CHD优于国际糖尿病联合会的定义。在调整了组件之后，MetS失去了与CHD和CVA的关联;在该模型中，高血压和高空腹血糖（国际糖尿病联合会的定义）显示出发生CVA事件的重大风险;关于冠心病事件，血压升高，高空腹血糖，以及按照世界卫生组织的定义，肥胖和血脂异常仍然是预测因素。结论：MetS的所有定义均与CVA和CHD事件相关。在调整了组件之后，MetS失去了与事件CVA和CHD的关联;然而，在所有定义中，CVA和CHD事件的血压升高以及CHD事件的高空腹血浆葡萄糖仍然是独立的预测因子。

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