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首页> 外文期刊>Chemical Society Reviews >Hydrolases: catalytically promiscuous enzymes for non-conventional reactions in organic synthesis
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Hydrolases: catalytically promiscuous enzymes for non-conventional reactions in organic synthesis

机译：水解酶：有机合成中非常规反应的催化混杂酶

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摘要

During the last three decades the use of hydrolases for the catalysis of environmentally friendly organic processes under mild reaction conditions has been well documented. Hydrolases have shown themselves to be ideal tools for the acceleration of synthetic transformations because of their high stability, catalytic efficiency, commercial availability and broad substrate specificity in a wide spectrum of biocatalyzed processes. In recent years, novel examples have appeared related to non-conventional reactions catalyzed by hydrolytic enzymes. Amongst these, lipases and acylases have gained much attention as promiscuous biocatalysts showing good levels of reactivity in C-C bond formation, G-heteroatom bond formation, oxidative processes, and novel hydrolytic reactions. This critical review covers recent investigation in the field of catalytic promiscuity, and highlights the most surprising and uncommon activities that this class of enzymes shows in organic synthetic transformations (111 references).
机译：在过去的三十年中，水解酶在温和的反应条件下催化对环境友好的有机过程的催化作用已广为人知。水解酶因其在各种生物催化过程中的高稳定性，催化效率，商业可得性和广泛的底物特异性而显示出它们是加速合成转化的理想工具。近年来，出现了与水解酶催化的非常规反应有关的新例子。其中，脂肪酶和酰基转移酶作为混杂的生物催化剂，在C-C键形成，G-杂原子键形成，氧化过程和新的水解反应中显示出良好的反应性，因此受到了广泛的关注。这项重要的综述涵盖了催化混杂领域的最新研究，并强调了这类酶在有机合成转化中显示出的最令人惊讶和最不常见的活性（111个参考文献）。

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