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首页> 外文期刊>Surgical Endoscopy >Single-Access Fetal Endoscopy (SAFE) for myelomeningocele in sheep model I: Amniotic carbon dioxide gas approach
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Single-Access Fetal Endoscopy (SAFE) for myelomeningocele in sheep model I: Amniotic carbon dioxide gas approach

机译：绵羊模型I的单次进入胎儿内窥镜检查（SAFE）：羊膜二氧化碳气法

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Background: This study aimed to assess the feasibility of single-access fetal endoscopy (SAFE) for the management of myelomeningocele (MMC) using intrauterine carbon dioxide as a distension medium in a sheep model. Methods: This prospective experimental case-control study investigated 12 lamb fetuses that had a myelomeningocele-like defect surgically created on the 75th day of gestation. Four fetuses remained untreated (control group), and eight fetuses had MMC repair using two fetoscopic approaches with carbon dioxide used to distend the amniotic cavity. A collagen patch was placed over the defect and secured with surgical sealant. Four animals had a two-port fetoscopic procedure, and four animals had SAFE. Clinical and pathologic studies were performed after delivery. Results: This study confirmed the validity of the animal MMC model. None of the control animals was able to stand or walk, and all had a significant defect in the lumbar area with continuous leakage of cerebrospinal fluid, ventriculomegaly, and a Chiari-II malformation. All the treated animals, independently of the number of ports used in the repair, were able to walk and had a closed defect with resolution of the Chiari malformation. Conclusions: The SAFE patch and glue coverage of surgically created fetal MMC is feasible and effective in restoring gross neurologic function in the fetal lamb model.
机译：背景：本研究旨在评估在绵羊模型中使用子宫内二氧化碳作为扩张介质的单次胎儿内窥镜检查（SAFE）在管理脊髓膜腔积液（MMC）中的可行性。方法：这项前瞻性实验病例对照研究调查了在妊娠第75天通过手术制造的12例羊胎，这些胎具有外科手术所产生的脊髓膜样膨出样缺损。四名胎儿仍未接受治疗（对照组），八名胎儿使用两种胎儿镜检查方法进行了MMC修复，其中二氧化碳用于扩张羊膜腔。将胶原蛋白贴剂放置在缺损上并用手术密封剂固定。四只动物进行了两口镜检查，四只动物进行了安全检查。分娩后进行临床和病理学研究。结果：这项研究证实了动物MMC模型的有效性。对照动物中没有一个能够站立或行走，并且所有人的腰椎区域都有明显的缺陷，其中脑脊液不断漏出，脑室肥大和Chiari-II畸形。所有被治疗的动物，无论用于修复的端口数量如何，都能够行走并具有闭合性缺损，可解决Chiari畸形。结论：通过手术创建的胎儿MMC的SAFE贴片和胶水覆盖对于恢复胎羊模型的总体神经功能是可行和有效的。

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