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首页> 外文期刊>Surgical Endoscopy >Combined pretherapeutic endoscopic and laparoscopic ultrasonography may predict survival of patients with upper gastrointestinal tract cancer.
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Combined pretherapeutic endoscopic and laparoscopic ultrasonography may predict survival of patients with upper gastrointestinal tract cancer.

机译：联合治疗前内镜和腹腔镜超声检查可以预测上消化道癌患者的生存率。

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摘要

BACKGROUND: The combination of endoscopic and laparoscopic ultrasonography (EUS-LUS) is accurate for resectability assessment of patients with upper gastrointestinal cancer (UGIC). But neither the ability of EUS/LUS to predict long-term prognosis nor the potential impact on patient survival using this selection strategy has been investigated. This prospective, single-center study evaluated whether pretherapeutic EUS-LUS stratification related to the prognosis in UGIC patients and whether patient selection by this strategy provided a prognostic outcome comparable with survival data from the literature. METHODS: Each patient had a pretherapeutic tumor node metastasis (TNM) stage and a resectability assessment assigned based on EUS-LUS findings. Survival curves were constructed and compared for each of the EUS-LUS TNM stage and resectability groups at the end of the observation period. Finally, the R0 resection rate, median, and 5-year survival rates were compared with the literature. RESULTS: This study enrolled 936 consecutive patients with esophageal (n = 256), gastric (n = 273), or pancreatic (n = 407) cancer. A statistically significant survival difference (p < 0.01) between the different TNM stages and resectability groups predicted by EUS-LUS was observed regardless of the cancer type. The poor prognosis for the patients with irresectable or disseminated UGIC was accurately predicted by EUS and LUS. The R0 resection rate as well as the median and 5-year survival rates were comparable with data from the literature. CONCLUSION: The pretherapeutic EUS-LUS patient stratification related significantly to the final prognosis for UGIC patients. An EUS-LUS-based patient selection strategy seemed to provide a prognostic outcome similar to data from computed tomography (CT)-based populations.
机译：背景：内镜和腹腔镜超声检查（EUS-LUS）的结合可准确评估上消化道癌（UGIC）患者的可切除性。但是，既未研究EUS / LUS预测长期预后的能力，也未研究使用这种选择策略对患者生存的潜在影响。这项前瞻性，单中心研究评估了治疗前的EUS-LUS分层是否与UGIC患者的预后有关，以及通过这种策略选择患者是否提供了与文献中的生存数据相当的预后结果。方法：每例患者均进行了治疗前的肿瘤转移（TNM）分期，并根据EUS-LUS的发现进行了可切除性评估。在观察期结束时，构建并比较每个EUS-LUS TNM阶段和可切除性组的生存曲线。最后，将R0切除率，中位数和5年生存率与文献进行了比较。结果：本研究连续纳入了936例食管癌（n = 256），胃癌（n = 273）或胰腺癌（n = 407）的患者。无论癌症类型如何，在EUS-LUS预测的不同TNM分期和可切除性组之间，存在统计学上显着的生存差异（p <0.01）。 EUS和LUS准确地预测了不可切除或弥散性UGIC患者的预后不良。 R0切除率以及中位和5年生存率与文献数据相当。结论：治疗前的EUS-LUS患者分层与UGIC患者的最终预后显着相关。基于EUS-LUS的患者选择策略似乎提供了与基于计算机断层扫描（CT）人群的数据相似的预后结果。

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