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首页> 外文期刊>Surgical Endoscopy >Determination of cardiorespiratory function and the optimum anesthetic regimen during laparoscopic surgery in the rat model.
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Determination of cardiorespiratory function and the optimum anesthetic regimen during laparoscopic surgery in the rat model.

机译：在大鼠模型中腹腔镜手术期间确定心肺功能和最佳麻醉方案。

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BACKGROUND: The rat is increasingly being used in laparoscopic research yet the hemodynamic and respiratory effects of CO2 pneumoperitoneum have not been studied in this model. METHODS: Five Lewis rats were anesthetized with inhaled isoflurane (1.4-2.0%) and a 50% O2/50% N2O mixture by mask (ISO). Another five rats were anesthetized with 1 ml/kg intraperitoneal sodium pentobarbital (PB) and given 100% O2 by mask. Catheters were placed in the femoral artery and the right jugular vein and a thermistor probe was placed in the aortic arch. Heart rate (HR), blood pressure (MAP), cardiac index (CI), arterial pH, and PCO2 were measured at baseline and following 10, 20, and 30 min of 2 mmHg CO2 pneumoperitoneum. RESULTS: CO2 pneumoperitoneum had no effect on HR, MAP, CI, pH, or PCO2 in either the ISO or PB anesthetic groups. Comparing the two anesthetic groups, PB demonstrated a significantly higher MAP at all time points, a significantly higher PCO2 at baseline, and 10 min of pneumoperitoneum, a significantlylower pH at baseline, 10, and 30 minutes of pneumoperitoneum, and a significantly longer induction time (31 vs. 6 min). There was no difference in HR or CI between the two anesthetics. CONCLUSION: Low-pressure CO2 pneumoperitoneum up to 30 min in the spontaneously breathing rat does not significantly affect HR, MAP, CI, pH, or PCO2. Inhalational isoflurance/N2O anesthesia produces less hypertension and respiratory acidosis than intraperitoneal pentobarbital during pneumoperitoneum in the rat.
机译：背景：大鼠越来越多地用于腹腔镜研究，但尚未在该模型中研究CO2气腹的血液动力学和呼吸作用。方法：五只Lewis大鼠用吸入异氟烷（1.4-2.0％）和50％O2 / 50％N2O混合面罩（ISO）麻醉。另一只五只大鼠用1 ml / kg腹膜内戊巴比妥钠（PB）麻醉，并通过面罩给予100％O2。将导管放置在股动脉和右颈静脉中，并将热敏电阻探头放置在主动脉弓中。在基线和2 mmHg CO2气腹后10、20和30分钟后，测量心率（HR），血压（MAP），心脏指数（CI），动脉pH和PCO2。结果：在ISO或PB麻醉组中，CO2气腹对HR，MAP，CI，pH或PCO2均无影响。比较两组麻醉剂，PB在所有时间点均显示出较高的MAP，基线时的PCO2显着较高，气腹10分钟，基线时的pH值显着降低，气腹10和30分钟，诱导时间明显更长。 （31分钟对6分钟）。两种麻醉剂的HR或CI没有差异。结论：自发性呼吸大鼠长达30分钟的低压CO2气腹不会显着影响HR，MAP，CI，pH或PCO2。在大鼠气腹期间，吸入异氟醚/ N2O麻醉所产生的高血压和呼吸性酸中毒少于腹膜内戊巴比妥。

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