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首页> 外文期刊>Surgical Endoscopy >Histologic evaluation of fetal brains following maternal pneumoperitoneum.
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Histologic evaluation of fetal brains following maternal pneumoperitoneum.

机译：产妇气腹后胎儿大脑的组织学评估。

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摘要

BACKGROUND: The purpose of this study was to determine if maternal pneumoperitoneum with carbon dioxide (CO2) produces evidence of central nervous system (CNS) injury in preterm fetal guinea pigs. METHODS: Thirty pregnant guinea pigs at gestational day (GD) 45 were assigned at random to one of three treatment groups: anesthesia only, CO2 pneumoperitoneum (5 mmHg), or laparotomy. Dams were killed 3 or 5 days postprocedure and fetal brains (83 total) harvested and fixed for subsequent histopathologic evaluation. For comparative purposes, histologic features of fetal guinea pig brain injury were defined from examination of fetal brains harvested from an additional dam that underwent laparotomy with 20 min of uterine arterial occlusion. RESULTS: Carbon dioxide pneumoperitoneum did not increase maternal/fetal morbidity. No evidence of brain injury was found in fetuses from any of the treatment groups. CONCLUSION: Carbon dioxide pneumoperitoneum at 5 mmHg for 40 min in the pregnant guinea pig does not produce evidence of fetal brain injury.
机译：摘要背景：这项研究的目的是确定母体气腹二氧化碳（CO2）是否能在早产儿豚鼠中产生中枢神经系统（CNS）损伤的证据。方法：将30只妊娠豚鼠在妊娠第45天（GD）随机分配到以下三个治疗组之一：仅麻醉，CO2气腹（5 mmHg）或剖腹手术。在手术后3或5天杀死大坝，并收集胎脑（共83个）并固定以用于随后的组织病理学评估。为了进行比较，通过检查从另一只大坝收获的胎儿大脑检查了胎儿豚鼠脑损伤的组织学特征，这些大坝在20分钟的子宫动脉闭塞后进行了剖腹手术。结果：二氧化碳气腹并没有增加产妇/胎儿的发病率。在任何治疗组的胎儿中均未发现脑损伤的证据。结论：妊娠豚鼠在5 mmHg处进行40分钟的二氧化碳气腹不能产生胎儿脑损伤的证据。

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