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首页> 外文期刊>Surgical Endoscopy >Clonidine provides opioid-sparing effect, stable hemodynamics, and renal integrity during laparoscopic cholecystectomy.
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Clonidine provides opioid-sparing effect, stable hemodynamics, and renal integrity during laparoscopic cholecystectomy.

机译：可乐定可在腹腔镜胆囊切除术中提供阿片类药物的保护作用，稳定的血流动力学和肾脏完整性。

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BACKGROUND: Carbon dioxide pneumoperitoneum causes a hemodynamic stress response and decreases urine output because of an activated renin-angiotensin-aldosterone system (RAAS). Clonidine is a potent antihypertensive drug that suppresses RAAS. METHODS: The effects of clonidine 4.5 mg/kg or saline on hemodynamics, neuroendocrine response, and renal parameters were compared in 30 healthy patients undergoing laparoscopic cholecystectomy. RESULTS: Heart rate, arterial blood pressures, and plasma renin activity were lower during and after pneumoperitoneum in patients with clonidine. There were no differences in urine output, urine oxygen tension (reflecting medullary perfusion), or antidiuretic hormone between the groups. N-acetyl-b-D-glucosaminidase, a marker of proximal tubular damage, was minimally elevated after clonidine. CONCLUSIONS: Clonidine enabled stable hemodynamics and prevented activation of RAAS seen as unchanged plasma renin activity. Clonidine may be beneficial during laparoscopy in patients with hypertension, cardiovascular, and/or renal diseases.
机译：背景：由于激活的肾素-血管紧张素-醛固酮系统（RAAS），二氧化碳气腹会引起血流动力学应激反应并减少尿量。可乐定是一种有效的降压药，可抑制RAAS。方法：比较了30例接受腹腔镜胆囊切除术的健康患者的可乐定4.5 mg / kg或生理盐水对血液动力学，神经内分泌反应和肾脏参数的影响。结果：可乐定患者在气腹期间和术后心率，动脉血压和血浆肾素活性较低。两组之间的尿量，尿液氧张力（反映髓质灌注）或抗利尿激素没有差异。 N-乙酰基-b-D-氨基葡萄糖苷酶（近端肾小管损伤的标志物）在可乐定治疗后最低程度升高。结论：可乐定可实现稳定的血流动力学，并防止RAAS活化（血浆肾素活性不变）。在患有高血压，心血管和/或肾脏疾病的患者进行腹腔镜检查时，可乐定可能是有益的。

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