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首页> 外文期刊>Surgical Endoscopy >The influence of adhesion prophylactic substances and taurolidine/heparin on local recurrence and intraperitoneal tumor growth after laparoscopic-assisted bowel resection of colon carcinoma in a rat model.
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The influence of adhesion prophylactic substances and taurolidine/heparin on local recurrence and intraperitoneal tumor growth after laparoscopic-assisted bowel resection of colon carcinoma in a rat model.

机译：腹腔镜辅助肠切除结肠癌大鼠模型中黏附性预防物质和牛磺吡啶/肝素对局部复发和腹膜内肿瘤生长的影响。

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BACKGROUND: The goal of the study was to investigate the influence of adhesion prophylactic substances (Interceed/lntergel) as well as taurolidine/heparin on intraperitoneal tumor growth and the local recurrence rate after laparoscopic cecum resection in a rat tumor model. METHODS: Sixty BDIX rats were randomized in three therapy groups and one control group. A laparoscopic-assisted cecum resection was performed via three-trocar method after intraperitoneal tumor cell application (10,000 cells) of a colon carcinoma cell line (DHD/K1/TRb) in all animals. According to the randomization, the cecum suture and a 1 x 1-cm peritoneal defect were either covered with Intergel/Interceed or 1 ml of 0.5% taurolidine 10 IU heparin. The control group underwent instillation of 1 ml 0.9% NaCl solution. After 4 weeks the animals were euthanized and intraperitoneal tumor growth, local recurrence rate, and the number of intraperitoneal adhesions were determined. RESULTS: The local recurrence rate was not significantly affected by any of the substances. Nevertheless, taurolidine/heparin significantly reduced the total number and weight of intraperitoneal metastases. The formation of adhesions was not significantly influenced by adhesion prophylaxis substances or by taurolidine/heparin. CONCLUSIONS: Taurolidine/heparin led to a significant reduction of intraperitoneal tumor growth after intraperitoneal application, whereas local tumor recurrence was not significantly influenced. This might be due to the number of injected tumor cells in this cell suspension model. Interceed and Intergel did not reduce intraperitoneal tumor growth. Furthermore, adhesion formation was not reduced by any of the substances.
机译：背景：本研究的目的是研究在大鼠肿瘤模型中腹腔镜盲肠切除术后预防粘连性物质（Interceed / Intergel）以及牛磺吡啶/肝素对腹膜内肿瘤生长和局部复发率的影响。方法：将60只BDIX大鼠随机分为3个治疗组和1个对照组。腹腔镜辅助盲肠切除术在所有动物中均在腹腔内应用结肠癌细胞系（DHD / K1 / TRb）的肿瘤细胞（10,000个细胞）后进行三套管针法。根据随机分组，用Intergel / Interceed或1 ml 0.5％的taurolidine 10 IU肝素覆盖盲肠缝合线和1 x 1 cm腹膜缺损。对照组滴入1ml 0.9％NaCl溶液。 4周后，对动物实施安乐死并确定腹膜内肿瘤的生长，局部复发率和腹膜内粘连的数量。结果：局部复发率不受任何物质的显着影响。然而，牛磺洛定/肝素显着减少了腹膜内转移的总数和重量。粘连的形成不受粘连预防物质或taurolidine /肝素的影响。结论：牛磺酸/肝素导致腹膜内应用后腹膜内肿瘤的生长明显减少，而局部肿瘤的复发并未受到明显影响。这可能是由于在该细胞悬液模型中注射的肿瘤细胞的数量。 Interceed和Intergel均未降低腹膜内肿瘤的生长。此外，任何物质都不会减少粘附形成。

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