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首页> 外文期刊>Surgical Endoscopy >Influence of different pneumoperitoneal pressures on tumor cell distribution in rats.
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Influence of different pneumoperitoneal pressures on tumor cell distribution in rats.

机译：不同的气腹压力对大鼠肿瘤细胞分布的影响。

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摘要

BACKGROUND: The effect of different pneumoperitoneal pressures on tumor cell distribution was investigated. METHODS: Donryu rats were allocated to receive carbon dioxide pneumoperitoneum at 5, 10, or 15 mmHg for 60 min or to serve as a control. During the procedure, each rat was inoculated with radiolabeled ascites hepatoma cells via the portal vein (experiment 1) or femoral vein (experiment 2). In both experiments, the rats were killed 30, 60, 90, or 120 min after tumor cell inoculation, and the liver and lungs were extirpated for radioactivity count (n = 5 or 6 for each time point in each group). RESULTS: In experiment 1, the percentage of injected dose (% ID) for the liver was greater than for the other three groups 120 min after tumor cell inoculation. There were no significant differences in the %IDs of the lungs at any time point among the groups. In experiment 2, there were no significant differences in the %IDs of the liver and lungs at any time point among the groups. CONCLUSIONS: These results suggest that an elevated insufflation pressure facilitates the location of intraportally injected tumor cells in the liver, and that pulmonary location of the tumor cells may not depend on insufflation pressures in this animal model.
机译：背景：研究了不同的气腹压力对肿瘤细胞分布的影响。方法：将Donryu大鼠分为5、10或15 mmHg接受60分钟的二氧化碳气腹或作为对照。在该过程中，通过门静脉（实验1）或股静脉（实验2）给每只大鼠接种放射性标记的腹水肝癌细胞。在两个实验中，均在接种肿瘤细胞后30、60、90或120分钟处死大鼠，并切除肝和肺的放射性计数（每组每个时间点n = 5或6）。结果：在实验1中，肿瘤细胞接种120分钟后，肝脏的注射剂量百分比（％ID）大于其他三组。各组之间在任何时间点的肺％IDs均无显着差异。在实验2中，各组之间在任何时间点的肝和肺的％IDs均无显着差异。结论：这些结果表明升高的吹入压力有助于肝内经腔内注射的肿瘤细胞的定位，并且在该动物模型中肿瘤细胞的肺部位置可能不取决于吹入压力。

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