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首页> 外文期刊>Surgical Endoscopy >Prevention of postoperative nausea and vomiting with a small dose of propofol alone and combined with dexamethasone in patients undergoing laparoscopic cholecystectomy: A prospective, randomized, double-blind study.
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Prevention of postoperative nausea and vomiting with a small dose of propofol alone and combined with dexamethasone in patients undergoing laparoscopic cholecystectomy: A prospective, randomized, double-blind study.

机译：腹腔镜胆囊切除术患者单独使用小剂量异丙酚联合地塞米松预防术后恶心和呕吐：一项前瞻性，随机，双盲研究。

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BACKGROUND: A small dose of propofol is directly antiemetic, and is effective for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy (LC). However, this regimen cannot entirely control PONV after LC. METHODS: In a prospective, randomized, double-blind study, patients received intravenously either placebo (Intralipid), propofol 0.5 mg/kg, or propofol 0.5 mg/kg plus dexamethasone 8 mg at the end of surgical procedure. A standard anesthetic technique, including sevoflurane and air in oxygen, was used. Emetic symptoms (nausea, retching, and vomiting) were recorded during the first 24 hours after anesthesia. RESULTS: A total of 120 patients (59 men and 61 nonpregnant women) were enrolled, and each treatment group consisted of 40 patients. The incidence of patients experiencing PONV during the first 24 hours after anesthesia was 33% with propofol (P = 0.003), 15% with propofol plus dexamethasone (P = 0.001), when compared to 65% with placebo. The efficacy of propofol combined with dexamethasone was superior to that of propofol alone (P = 0.029). No clinically important adverse events due to the study drugs were observed in any of the groups. CONCLUSIONS: Propofol 0.5 mg/kg combined with dexamethasone 8 mg is more effective than propofol alone for the prevention of PONV during the first 24 hours after anesthesia in patients undergoing LC.
机译：背景：小剂量的异丙酚是直接止吐药，对预防腹腔镜胆囊切除术（LC）的患者的恶心和呕吐（PONV）有预防作用。但是，该方案不能完全控制LC后的PONV。方法：在一项前瞻性，随机，双盲研究中，在手术结束时，患者接受静脉内安慰剂（Intralipid），丙泊酚0.5 mg / kg或丙泊酚0.5 mg / kg加地塞米松8 mg静脉注射。使用了标准的麻醉技术，包括七氟醚和氧气中的空气。在麻醉后的最初24小时内记录呕吐症状（恶心，呕吐和呕吐）。结果：共纳入120例患者（男59例，非孕61例），每个治疗组40例。麻醉后最初24小时内接受PONV的患者发生率为33％（丙泊酚）（P = 0.003），丙泊酚加地塞米松15％（P = 0.001），而安慰剂组为65％。丙泊酚联合地塞米松的疗效优于单独使用丙泊酚的疗效（P = 0.029）。在任何一组中均未观察到由于研究药物引起的临床上重要的不良事件。结论：在LC患者麻醉后的最初24小时内，丙泊酚0.5 mg / kg联合地塞米松8 mg在预防PONV方面比单独使用丙泊酚更为有效。

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