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首页> 外文期刊>Cartilage >Therapeutic Effects of Intra-Articular Ultrapurified Low Endotoxin Alginate Administration on Experimental Osteoarthritis in Rabbits
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Therapeutic Effects of Intra-Articular Ultrapurified Low Endotoxin Alginate Administration on Experimental Osteoarthritis in Rabbits

机译：关节内超纯化低内毒素藻酸盐的给药对实验性骨关节炎的治疗作用

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Objective: We have developed an ultrapurified low endotoxin alginate (UPLE alginate), which can drastically reduce endotoxin levels. Our purposes were to examine the effects of UPLE alginate administration on osteoarthritis (OA) progression and to determine the adequate molecular weight of the UPLE alginate for therapeutic effects. Design: To induce knee OA, 35 Japanese White rabbits underwent anterior cruciate ligament transection. Intra-articular injections of 0.3 mL solution of each material were started at 4 weeks postoperatively for a total of 5 weekly injections. Seventy knees were divided into the following groups: AL430 (430 kDa molecular weight UPLE alginate), AL1000 (1,000 kDa), AL1700 (1,700 kDa), HA (hyaluronan), and NS (normal saline). At 9 weeks postoperatively, all knees were assessed macroscopically, histologically, and mechanically. Results: Macroscopically, the UPLE alginate groups exhibited milder cartilage degradation compared to that of the NS and HA groups. Histological findings of the UPLE alginate groups showed an obvious reduction in the severity of OA. The histological scores of Kikuchiet al.were superior in the alginate treatment groups compared to the NS group. The friction coefficient of the AL1000 group was significantly lower than that of the NS and HA groups. Conclusion: This study indicates that our UPLE alginates, especially AL1000, have promising potential as an effective agent in preventing OA progression.
机译：目的：我们开发了一种超纯化的低内毒素海藻酸盐（UPLE海藻酸盐），可大幅降低内毒素水平。我们的目的是检查UPLE海藻酸盐对骨关节炎（OA）进展的影响，并确定UPLE海藻酸盐的适当分子量以达到治疗效果。设计：为了诱发膝骨关节炎，对35只日本白兔进行了前交叉韧带横断术。在术后4周开始每种材料的0.3mL溶液的关节内注射，总共5周。将70个膝盖分为以下几组：AL430（分子量为430 kDa的UPLE海藻酸盐），AL1000（1,000 kDa），AL1700（1,700 kDa），HA（透明质酸）和NS（生理盐水）。术后9周，对所有膝盖进行宏观，组织学和机械评估。结果：宏观上，与NS组和HA组相比，UPLE藻酸盐组的软骨降解程度较轻。 UPLE藻酸盐组的组织学发现显示OA的严重程度明显降低。与NS组相比，藻酸盐治疗组的Kikuchiet等人的组织学评分更高。 AL1000组的摩擦系数明显低于NS组和HA组。结论：这项研究表明，我们的UPLE藻酸盐，尤其是AL1000，有望成为预防OA进展的有效药物。

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