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首页> 外文期刊>Cartilage >Cell-Seeded Collagen Matrix-Supported Autologous Chondrocyte Transplantation (ACT-CS): A Consensus Statement on Surgical Technique
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Cell-Seeded Collagen Matrix-Supported Autologous Chondrocyte Transplantation (ACT-CS): A Consensus Statement on Surgical Technique

机译：细胞播种的胶原蛋白基质支持的自体软骨细胞移植（ACT-CS）：外科技术的共识声明。

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Objective: Autologous chondrocyte transplantation has become an established therapy for full-thickness cartilage defects. Cell-seeded collagen matrix-supported autologous chondrocyte transplantation (ACT-CS) has been introduced as a modification of conventional ACT, which allows easier handling and is intended to combine the advantages of using a cell suspension (i.e., cell viability and mitotic activity) with the stability and self-containment provided by a matrix of biomaterials. Unlike other techniques and products, this seeding step can be easily applied using a porcine collagen type I/III membrane and autologous chondrocytes in an operating room setting. Although some suturing is required, this technique provides the distinct advantage of not requiring a water-tight seal of the bilayer membrane, as is required using the classic cell suspension technique. Comparable to other modifications of ACT, the ACT-CS procedure requires a specific surgical technique that focuses on the following important details: (1) accurate debridement of the cartilage defect; (2) preparation of the cells, and seeding and containment of the cells within the transplantation site; and (3) sealing and suturing around the defect. Design: A consensus meeting of leading European orthopedic surgeons specializing in cartilage repair was convened to discuss and standardize the surgical aspects of this technique. Results & Conclusions: The present article describes and discusses the adoption of these best surgical practices for implementing the ACT-CS technique, including more detailed descriptions of each phase of the surgery in order to standardize and optimize patient outcomes.
机译：目的：自体软骨细胞移植已成为治疗全层软骨缺损的公认方法。作为常规ACT的改良，已引入了由细胞播种的胶原蛋白基质支持的自体软骨细胞移植（ACT-CS），该方法使操作更容易，并且旨在结合使用细胞悬液的优势（即细胞活力和有丝分裂活性）以及由生物材料基质提供的稳定性和自我控制。与其他技术和产品不同，可以在手术室环境中使用猪I / III型胶原蛋白膜和自体软骨细胞轻松实施该接种步骤。尽管需要进行一些缝合，但该技术具有不像传统细胞悬浮技术那样需要水密密封双层膜的独特优势。与ACT的其他修改相比，ACT-CS程序需要一种专门的手术技术，其重点是以下重要细节：（1）软骨缺损的准确清创术; （2）准备细胞，并在移植部位内接种和容纳细胞; （3）密封和缝合缺损处。设计：召集专门从事软骨修复的欧洲骨科领先外科医师共识会议，以讨论和标准化该技术的手术方面。结果与结论：本文描述并讨论了采用最佳手术实践来实施ACT-CS技术的过程，包括对手术各阶段的更详细描述，以标准化和优化患者预后。

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