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Supporting Biomaterials for Articular Cartilage Repair

机译：支持关节软骨修复的生物材料

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摘要

Orthopedic surgeons and researchers worldwide are continuously faced with the challenge of regenerating articular cartilage defects. However, until now, it has not been possible to completely mimic the biological and biochemical properties of articular cartilage using current research and development approaches. In this review, biomaterials previously used for articular cartilage repair research are addressed. Furthermore, a brief discussion of the state of the art of current cell printing procedures mimicking native cartilage is offered in light of their use as future alternatives for cartilage tissue engineering. Inkjet cell printing, controlled deposition cell printing tools, and laser cell printing are cutting-edge techniques in this context. The development of mimetic hydrogels with specific biological properties relevant to articular cartilage native tissue will support the development of improved, functional, and novel engineered tissue for clinical application.
机译：全世界的骨科医生和研究人员一直面临着再生关节软骨缺损的挑战。然而，直到现在，还不能使用当前的研究和开发方法来完全模拟关节软骨的生物学和生化特性。在这篇评论中，解决了以前用于关节软骨修复研究的生物材料。此外，鉴于其作为软骨组织工程的未来替代品的用途，提供了关于模拟天然软骨的当前细胞印刷程序的技术水平的简要讨论。在这种情况下，喷墨单元打印，受控沉积单元打印工具和激光单元打印是最先进的技术。具有与关节软骨天然组织相关的特定生物学特性的模拟水凝胶的开发将支持临床应用的改进，功能和新型工程组织的开发。

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