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首页> 外文期刊>Surgical Endoscopy >Peritoneal closure reduces port site metastases: results of an experiment in a rat ovarian cancer model.
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Peritoneal closure reduces port site metastases: results of an experiment in a rat ovarian cancer model.

机译：腹膜封闭可减少端口部位转移：在大鼠卵巢癌模型中的实验结果。

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BACKGROUND: The arm of this study was to assess the role of peritoneal closure in the prevention of port site metastasis after carbon dioxide (CO2) CO2 pneumoperitoneum. METHODS: We developed a xenograft ovarian cancer model by intraperitoneal injection of 27 106 IGR-OV1 line cells in nude rats Seven days after the inoculation, the animals underwent a CO2 pneumoperitoneum. At the end of the procedure, port sites were randomly closed either with suture of peritoneum (n = 14, group A) or without suture of peritoneum (n = 12, group B). The rats were killed 7 days after surgery and their port site scars were resected. Tumor implantation was assessed by a pathologist who was blinded to the type of wound closure. RESULTS: The animals in group B were significantly more likely to have at least one port site metastasis frequent (seven of 12, or 58.3%) than those in group A (two of 14, or (14.3%) (p = 0.037). Port sites with metastases were seen more frequently in group B (eight of 24, or (33.3%) than in group A (three of 28, or 10.7%) (p = 0.046). CONCLUSIONS: Our results shows that peritoneum closure decreases the risk of port site metastasis.
机译：背景：这项研究的目的是评估腹膜封闭在预防二氧化碳（CO2），CO2气腹后端口位转移中的作用。方法：我们通过在裸鼠中腹膜内注射27 106 IGR-OV1细胞，建立了异种移植卵巢癌模型。接种后7天，动物接受了CO2气腹。手术结束时，将腹膜缝合（n = 14，A组）或不缝合腹膜（n = 12，B组），将端口部位随机关闭。手术后7天将大鼠杀死，并切除其端口部位的疤痕。病理学家对伤口植入的类型视而不见，对肿瘤植入进行了评估。结果：与A组（14只中的两只，或（14.3％））相比，B组中的动物至少有一个频繁发生至少一个端口部位转移的可能性（12个中的七个，或58.3％）（p = 0.037）。在B组（24个，占83.3％）（33.3％）比A组（28个，占10.7％）三个部位更易发生转移（P = 0.046）。结论：我们的结果表明腹膜封闭降低了腹膜转移的发生率。发生端口转移的风险。

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