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首页> 外文期刊>Biomaterials >In vivo efficacy of a silicone-cationic steroid antimicrobial coating to prevent implant-related infection
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In vivo efficacy of a silicone-cationic steroid antimicrobial coating to prevent implant-related infection

机译：有机硅阳离子类固醇抗菌涂层的体内功效，可防止植入物相关感染

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摘要

Active release antimicrobial coatings for medical devices have been developed to prevent and treat biofilm implant-related infections. To date, only a handful of coatings have been put into clinical use, with limited success. In this study, a novel antimicrobial compound was incorporated into a silicone (polydimethylsiloxane or PDMS) polymer to develop a novel active release coating that addressed several limitations of current device coatings. The efficacy of this coating was optimized using an in vitro flow cells system, then translated to an animal model of a simulated Type IIIB open fracture wherein well-established biofilms were used as initial inocula. Results indicated that the novel coating was able to prevent infection in 100% (9/9) of animals that were treated with biofilms and the novel coating (treatment group). In contrast, 100% (9/9) of animals that were inoculated with biofilms and not treated with the coating (positive control), did develop infection. Nine animals were used as negative controls, i.e., those that were not treated with biofilms, and showed a rate of infection of 11% (1/9). Eight animals were treated with the novel coating only to determine its effect on host tissue. Results indicated that the novel active release coating may have significant promise for future application to prevent biofilm implant-related infections in patients.
机译：已经开发出用于医疗设备的主动释放抗菌涂层，以预防和治疗生物膜植入物相关的感染。迄今为止，仅少数涂料已投入临床使用，但效果有限。在这项研究中，将一种新型的抗菌化合物掺入了一种有机硅（聚二甲基硅氧烷或PDMS）聚合物中，以开发出一种新型的活性释放涂层，该涂层解决了当前设备涂层的一些局限性。使用体外流通池系统优化了这种涂层的功效，然后将其转化为模拟的IIIB型开放性骨折的动物模型，其中使用完善的生物膜作为初始接种物。结果表明，新型涂层能够预防用生物膜和新型涂层（治疗组）治疗的动物中100％（9/9）的感染。相比之下，接种生物膜但未用包膜处理（阳性对照）的动物有100％（9/9）确实感染了。九只动物用作阴性对照，即未经生物膜处理的动物，其感染率为11％（1/9）。仅用新颖的涂层处理八只动物以确定其对宿主组织的作用。结果表明，这种新型的主动释放包衣有望为预防患者生物膜植入物相关感染的未来应用提供巨大的希望。

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