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首页> 外文期刊>Biomaterials >Neural cell type-specific responses to glycomimetic functionalized collagen.
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Neural cell type-specific responses to glycomimetic functionalized collagen.

机译：对拟糖官能化胶原蛋白的神经细胞类型特异性反应。

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Despite their noted functional role, glycans have had limited therapeutic use due to difficulties in synthesis and quick degradation in vivo. The recent discovery of glycomimetics has provided new opportunities for their application. In this study, we have functionalized type I collagen with peptide mimics of two glycans: (1) polysialic acid (PSA) and (2) an epitope first discovered on human natural killer cells (HNK-1). These glycans and their glycomimetic counterparts have been shown to be important regulators of repair following injury through their unique and phenotypically specific effects on neural behavior. We show that these molecules retain their bioactivity following functionalization to the collagen backbone. Grafted HNK-1 encouraged motor neuron outgrowth, while grafted PSA encouraged sensory and motor neuron outgrowth and enhanced Schwann cell proliferation and process extension. These data support the potential of glycomimetic-functionalized collagen as a biomaterial strategy to increase the efficiency of synaptic reconnection following nervous system injury.
机译：尽管聚糖具有显着的功能作用，但由于合成困难和体内快速降解，聚糖的治疗用途受到限制。糖模拟物的最新发现为其应用提供了新的机会。在这项研究中，我们用两种聚糖的肽模拟物功能化了I型胶原蛋白：（1）聚唾液酸（PSA）和（2）首次在人类自然杀伤细胞（HNK-1）上发现的表位。通过对神经行为的独特和表型特异性作用，这些聚糖及其类似物被证明是损伤后修复的重要调节剂。我们显示这些分子保留功能到胶原蛋白骨架后保留其生物活性。嫁接的HNK-1促进运动神经元的生长，而嫁接的PSA促进感觉和运动神经元的生长，并增强雪旺细胞的增殖和过程扩展。这些数据支持了仿糖官能化胶原蛋白作为生物材料策略的潜力，该策略可以提高神经系统损伤后突触重新连接的效率。

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