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Surgical strategies for colorectal liver metastases.

机译:大肠肝转移的手术策略。

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Colorectal cancer remains the second commonest cause of death from cancer in Western society. Nearly half of all patients will develop liver metastases and many will die with disease confined to the liver. The accepted modern definitions of resectability now mean that over twenty per cent of patients are now resectable (with operative mortality of >2%) with curative intent, and nearly one third will be alive, disease free, five years later. The use of additional techniques such as radiofrequency ablation may bring many more patients the possibility of long term survival. The introduction of new chemotherapy regimens, including those based on oxaliplatin may convert one third of non-resectable patients to resectability with curative intent. Therefore, in 2004 nearly one third of patients with disease confined to the liver can now look forward to possibly curative liver surgery.
机译:大肠癌仍然是西方社会死于癌症的第二大常见原因。所有患者中将近一半会发生肝转移,许多人死于局限于肝脏的疾病。现在公认的现代可切除性定义意味着,如今有百分之二十以上的患者可以根治性手术切除(手术死亡率> 2%),五年后将有近三分之一的患者活着,没有疾病。使用诸如射频消融之类的其他技术可能为更多患者带来长期生存的可能性。引入新的化学疗法,包括基于奥沙利铂的化学疗法,可能会将三分之一不可切除的患者转化为具有治愈意图的可切除性。因此,在2004年,将近三分之一的局限于肝脏的疾病患者现在有望进行可能的治愈性肝手术。

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