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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Impact on daily functioning and indirect/direct costs associated with chemotherapy-induced nausea and vomiting (CINV) in a U.S. population.
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Impact on daily functioning and indirect/direct costs associated with chemotherapy-induced nausea and vomiting (CINV) in a U.S. population.

机译：对美国人群中与化疗引起的恶心和呕吐（CINV）相关的日常功能和间接/直接费用的影响。

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PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of chemotherapy, but it may be prevented or mitigated with medications. Uncontrolled CINV can lead to reduced quality of life and can result in increased costs (due to health care utilization and missed work). We prospectively assessed the prevalence and burden of CINV in a US population. METHODS: Final analysis was performed on 178 patients, beginning chemotherapy during 2007-2008 at oncology specialty settings. Patients kept a diary recording use of antiemetic medications just before the start of chemotherapy and use of antiemetic medications, health care resources, and episodes of nausea and vomiting during the 5 days following. In addition, they completed a Functional Living Index-Emesis (FLIE) questionnaire and a Work Productivity and Assessment Inventory-Nausea and Vomiting assessment, to determine the impact of CINV on daily functioning and on work productivity, respectively. Physicians independently recorded prescribed medications and health care utilization. RESULTS: Of the patients, 61.2% reported experiencing CINV (34.3% with acute CINV and 58.4% with delayed CINV). Based on the FLIE assessment, 37.2% of all patients reported reduced daily functioning, and of those with poorly managed CINV, about 90% reported a significant impact on daily functioning. Total costs due to CINV were on average Dollars 778.58 per patient from the day of administration through the 5 days following the first cycle of chemotherapy; patients with more severe CINV typically had higher costs. CONCLUSIONS: CINV remains a significant problem among US patients, suggesting a need for more effective prophylaxis use in clinical practice.
机译：目的：化疗引起的恶心和呕吐（CINV）是化疗的一种令人衰弱的副作用，但可以通过药物预防或缓解。不受控制的CINV可能导致生活质量下降，并可能导致成本增加（由于医疗保健的利用和工作的缺失）。我们前瞻性评估了美国人群中CINV的患病率和负担。方法：最终分析了178例患者，从2007年至2008年在肿瘤学专业设置下开始化疗。患者在刚开始化疗之前记录日记，记录止吐药物的使用情况，并在接下来的5天内记录止吐药物的使用，医疗保健资源以及恶心和呕吐的发作。此外，他们还完成了功能性生活指数-呕吐（FLIE）调查问卷以及工作生产率和评估库存-恶心和呕吐评估，以分别确定CINV对日常工作和工作效率的影响。医师独立记录处方药和医疗保健利用率。结果：在这些患者中，有61.2％报告患有CINV（急性CINV为34.3％，延迟CINV为58.4％）。根据FLIE评估，在所有患者中，有37.2％的患者报告每日功能下降，而在CINV管理不佳的患者中，约90％的患者报告了对日常功能的重大影响。从给药之日起至化疗第一个周期后的5天，每位患者平均CINV造成的总费用为778.58美元; CINV较重的患者通常费用较高。结论：CINV仍然是美国患者中的重要问题，表明在临床实践中需要更有效地预防使用。

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