Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial

Abe Masakazu; Hirashima Yasuyuki; Kasamatsu Yuka; Kado Nobuhiro; Komeda Satomi; Kuji Shiho; Tanaka Aki; Takahashi Nobutaka; Takekuma Munetaka; Hihara Hanako; Ichikawa Yoshikazu; Itonaga Yui; Hirakawa Tomoko; Nasu Kaei; Miyagi Kanoko; Murakami Junko; Ito Kimihiko

首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial

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Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial

机译：奥氮平联合阿瑞匹坦，帕洛诺司琼和地塞米松在妇科癌症中预防以顺铂为基础的化疗引起的恶心和呕吐的功效和安全性：KCOG-G1301 II期试验

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Olanzapine is effective in chemotherapy-induced nausea and vomiting (CINV). In patients receiving highly emetogenic chemotherapy (HEC), its efficacy was reported as rescue therapy for breakthrough emesis refractory to triplet therapy (palonosetron, aprepitant, and dexamethasone). However, its preventive effects with triplet therapy for CINV are unknown. This study aimed to investigate efficacy and safety of preventive use of olanzapine with triplet therapy for CINV of HEC.

机译：奥氮平对化疗引起的恶心和呕吐（CINV）有效。据报道，在接受高促呕吐化疗（HEC）的患者中，其功效可作为三联疗法（帕洛诺司琼，阿瑞匹坦和地塞米松）难治的突破性呕吐的抢救疗法。但是，尚不清楚三联疗法对CINV的预防作用。这项研究旨在调查预防性使用奥氮平联合三联疗法治疗HEC CINV的有效性和安全性。

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《Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer》 |2016年第2期|共8页
作者
Abe Masakazu; Hirashima Yasuyuki; Kasamatsu Yuka; Kado Nobuhiro; Komeda Satomi; Kuji Shiho; Tanaka Aki; Takahashi Nobutaka; Takekuma Munetaka; Hihara Hanako; Ichikawa Yoshikazu; Itonaga Yui; Hirakawa Tomoko; Nasu Kaei; Miyagi Kanoko; Murakami Junko; Ito Kimihiko;
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正文语种 eng
中图分类护理学;
关键词
Olanzapine; Chemotherapy-induced nausea and vomiting; Cisplatin; Highly-emetogenic chemotherapy; Antiemetic therapy;

机译：奥氮平;化学疗法引起的恶心和呕吐;顺铂;高催吐化学疗法;止吐疗法;

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1. Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial [J] . Abe Masakazu, Hirashima Yasuyuki, Kasamatsu Yuka, Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer . 2016,第2期

机译：奥氮平联合阿瑞匹坦，帕洛诺司琼和地塞米松在妇科癌症中预防以顺铂为基础的化疗引起的恶心和呕吐的功效和安全性：KCOG-G1301 II期试验
2. Phase III Randomized Trial of Palonosetron and Dexamethasone With or Without Aprepitant to Prevent Nausea and Vomiting Induced by Full-dose Single-day Cisplatin-based Chemotherapy in Lung Cancer [J] . Wu Fang, Lin Xiaoping, Yang Zhanghuan, Clinical lung cancer . 2018,第6期

机译：III期随机试验Palonosetron和地塞米松的试验有或没有共用，以防止通过全剂量单日顺铂基化疗在肺癌中诱导的恶心和呕吐
3. Efficacy and safety of 5 mg olanzapine combined with aprepitant, granisetron and dexamethasone to prevent carboplatin-induced nausea and vomiting in patients with gynecologic cancer: A multi-institution phase II study [J] . Iihara Hirotoshi, Shimokawa Mototsugu, Hayasaki Yoh, Gynecologic Oncology: An International Journal . 2020,第3期

机译：5毫克奥氮藻的功效和安全性联合用于治疗妇科癌症患者的卡铂诱导的恶心，呕吐：多机构期间II研究
4. The clinical efficacy of transfusion of cytokine-induced killer cells combined with chemotherapy and XiaoJi decoction in patients with stage IIIB/IV non-small cell lung cancer [C] . Liuning Li, Jiaying Liu, Xiaoshu Chai, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：细胞因子诱导的杀伤细胞输注结合化学疗法和消积汤治疗IIIB / IV期非小细胞肺癌的临床疗效
5. Aprepitant for the Prevention of Acute Chemotherapy-induced Nausea and Vomiting in Children: Overcoming Barriers [D] . Patel, Priya 2018

机译：预防急性化疗引起的儿童恶心和呕吐的阿瑞品：克服障碍
6. Phase II randomized controlled trial of 1 day versus 3 days of dexamethasone combined with palonosetron and aprepitant to prevent nausea and vomiting in Japanese breast cancer patients receiving anthracycline-based chemotherapy [O] . Yoshimasa Kosaka, Hirokazu Tanino, Norihiko Sengoku, -1

机译：II期随机对照试验在接受蒽环类化学疗法的日本乳腺癌患者中地塞米松联合帕洛诺司琼和阿瑞吡坦联合1天和3天预防恶心和呕吐
7. A Phase II study of palonosetron, aprepitant, dexamethasone and olanzapine for the prevention of cisplatin-based chemotherapy-induced nausea and vomiting in patients with thoracic malignancy [O] . Kazuhisa Nakashima, Haruyasu Murakami, Kouichi Yokoyama, 2017

机译：PalonoSetron，Affitepant，Dexamethasone和奥拉扎汀的II期研究，用于预防顺铂的化疗诱导的胸腔恶性肿瘤患者呕吐呕吐

Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial

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