...
【24h】

Diphenhydramine and acute kidney injury

机译:苯海拉明与急性肾损伤

获取原文
获取原文并翻译 | 示例
           

摘要

AKI cases, but not all drugs cause AKI by the same mechanism. For example, calcineurin inhibitors and vasopressors cause renal disease by vasoconstriction, whereas angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (AEBs), and nonsteroidal antiinflammatory drugs (NSAIDs) alter intraglomerular hemodynamics,Amphotericin B (e.g., AmBisome, Abelcet, Fungizone) is thought to lead to renal disease through tubular cell toxicity, and the use of acyclovir (Zovirax, GlaxoSmithKline) has been associated with crystal deposition in the kidneys.In addition, agents with anticholinergic properties, such as diphenhydramine, may lead to urinary retention, which can result in postrenal injury (see page 460). One case of diphenhydramine-induced renal disease involved a patient who presented with nontraumatic rhabdo-myolysis complicated by oliguric AKI following an intentional ethanol and diphenhydramine overdose.
机译:AKI病例,但并非所有药物都通过相同的机制引起AKI。例如,钙调神经磷酸酶抑制剂和血管加压药会通过血管收缩而导致肾脏疾病,而血管紧张素转化酶(ACE)抑制剂,血管紧张素受体阻滞剂(AEB)和非甾体抗炎药(NSAIDs)会改变肾小球内血流动力学,两性霉素B(例如AmBisome,Abelce (Fungizone)被认为可通过肾小管细胞毒性导致肾脏疾病,使用阿昔洛韦(Zovirax,GlaxoSmithKline)与肾脏中的晶体沉积有关,此外,具有抗胆碱能特性的药物如苯海拉明也可能导致尿retention留,可能导致肾后损伤(请参见第460页)。苯海拉明诱发的肾病1例,其中一名患者因非故意服用乙醇和苯海拉明过量而出现非创伤性横纹肌溶解症并伴有少尿性AKI。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号