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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome.
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Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome.

机译：奎尼丁引起两名Brugada综合征患者的心电图正常化。

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摘要

Two patients with Brugada syndrome are presented. The ECGs showed right precordial J waves and ST-segment elevation. Patient 1 was resuscitated from nocturnal ventricular fibrillation, patient 2 was asymptomatic. In only patient 1, flecainide was infused causing monomorphic "malignant" ventricular extrasystoles (R on T), demonstrating the deleterious effect of Class IC antiarrhythmic drugs in Brugada syndrome. However, administration of the Class Ia antiarrhythmic drug quinidine caused normalization of the ECG in both patients. Based on in vitro experiments, agents that reduce the magnitude of Ito-mediated phase 1 have been suggested to normalize ST-segment elevation in Brugada syndrome. This is the first clinical report of such a quinidine induced ECG normalization.
机译：介绍了两名患有Brugada综合征的患者。心电图显示右心前区J波和ST段抬高。患者1从夜间心室纤颤中恢复过来，患者2无症状。仅在患者1中，氟卡尼胺被注入后导致单形的“恶性”心室舒张前期（R代表T），表明IC类抗心律不齐药物对Brugada综合征具有有害作用。但是，Ia类抗心律不齐药物奎尼丁的使用导致两名患者的ECG正常化。根据体外实验，已提出降低Ito介导的1期幅度的药物可以使Brugada综合征的ST段抬高正常化。这是这种奎尼丁诱导的ECG正常化的首次临床报道。

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