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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Repolarization changes in a double-blind crossover study of dofetilide versus sotalol in the treatment of ventricular tachycardia.
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Repolarization changes in a double-blind crossover study of dofetilide versus sotalol in the treatment of ventricular tachycardia.

机译：多芬利特与索他洛尔治疗室性心动过速的双盲交叉研究中的复极变化。

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The aim of this study was to determine whether a therapeutic response to Class III antiarrhythmic drugs is related to predictable changes in repolarization on the electrocardiogram (ECG). A group of 57 patients with ischemic heart disease and inducible ventricular tachycardia (VT) at electrophysiological study (EPS) were selected from a population enrolled in a randomized double-blind crossover study of dofetilide (500 micrograms bid) versus sotalol (160 mg bid). ECGs were analyzed blindly, and RR, QT (maximum value/12 leads), QTc (Bazett's formula), QT dispersion (QTmax-QTmin over 12 leads) and QTc dispersion, were calculated at baseline and on the third day of treatment (4 hours after dosing), when patients underwent EPS to test the effects of study drugs on VT inducibility. RESULTS: At EPS 21 patients were responders to dofetilide and 22 to sotalol. On day 3, a significant increase in QT and QTc and decrease in QT and QTc dispersion, compared to baseline, was measured in responders and nonresponders, with both dofetilide and sotalol. No significant difference in QTc or QT dispersion between responders and nonresponders was observed in either treatment group. In conclusion, treatment with dofetilide and sotalol was associated with an increase in QT and QTc, and a decrease in QT and QTc dispersion. In contrast with previous reports, a differential effect on QT or QTc dispersion was not observed in drug responders versus nonresponders.
机译：这项研究的目的是确定对III类抗心律不齐药物的治疗反应是否与心电图（ECG）上复极的可预测变化有关。从参与多非利特（500毫克出价）与索他洛尔（160毫克出价）的随机双盲交叉研究的人群中选择一组57例在电生理研究（EPS）时发生缺血性心脏病和可诱发性室性心动过速（VT）的患者。对ECG进行盲法分析，并在基线和治疗的第三天计算RR，QT（最大值/ 12导联），QTc（Bazett公式），QT离散度（超过12导联的QTmax-QTmin）和QTc离散度（4给药后数小时），当患者接受EPS来测试研究药物对VT诱导能力的影响时。结果：在EPS时，多非利特有21例反应，索他洛尔有22例。在第3天，在同时使用多非利特和索他洛尔的应答者和非应答者中，与基线相比，QT和QTc显着升高，而QT和QTc离散度降低。在两个治疗组中，反应者和非反应者之间的QTc或QT离散度均无显着差异。总之，用多非利特和索他洛尔治疗与QT和QTc的增加，以及QT和QTc分散度的降低有关。与以前的报告相反，在药物应答者与非应答者中未观察到对QT或QTc分散的影响。

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