Asymmetric synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester: Formal synthesis of ramipril

Kondaiah G.C.M.; Vivekanandareddy M.; Reddy L.A.; Anurkar S.V.; Gurav V.M.; Ravikumar M.; Bhattacharya A.; Bandichhor R.

首页> 外文期刊>Synthetic Communications >Asymmetric synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester: Formal synthesis of ramipril

【24h】

Asymmetric synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester: Formal synthesis of ramipril

机译：（S，S，S）-2-氮杂-双环-[3.3.0]-辛烷-3-羧酸苄酯的不对称合成：雷米普利的形式合成

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3- carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.

机译：描述了不对称合成（S，S，S）-2-氮杂-双环-[3.3.0]-辛烷-3-羧酸苄酯2作为血管紧张素转化酶（ACE）抑制剂雷米普利1的中间体。

著录项

来源
《Synthetic Communications》 |2011年第9期|共6页
作者
Kondaiah G.C.M.; Vivekanandareddy M.; Reddy L.A.; Anurkar S.V.; Gurav V.M.; Ravikumar M.; Bhattacharya A.; Bandichhor R.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
(S)-1-Amino-2-methoxy methylpyrrolidine (SAMP); angiotensin converting enzyme (ACE) inhibitor; asymmetric synthesis; chiral auxiliary; enantiomerically pure ramipril;

机译：（S）-1-氨基-2-甲氧基甲基吡咯烷酮（SAMP）;血管紧张素转换酶（ACE）抑制剂;不对称合成;手性助剂;对映体纯雷米普利;

相似文献

外文文献
中文文献
专利

1. Asymmetric synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester: Formal synthesis of ramipril [J] . Kondaiah G.C.M., Vivekanandareddy M., Reddy L.A., Synthetic Communications . 2011,第7a9期

机译：（S，S，S）-2-氮杂-双环-[3.3.0]-辛烷-3-羧酸苄酯的不对称合成：雷米普利的形式合成
2. Transannular Cyclization in Cyclohexanes by Michael Addition of an Amine onto an alpha, beta-Unsaturated Ester: Synthesis of 8-Benzyl-8-azatricyclo[4.2.1.0]nonane-7-acetic Acid Ethyl Ester and 7-Benzyl-7-azabicyclo[2.2.1]heptane-l-acetic Acid Ethyl E [J] . Stephen J. Johnson The Journal of Organic Chemistry . 1995,第24期

机译：通过将胺加到α，β-不饱和酯上的胺加成环环己烷中的环环环化反应：合成8-苄基-8-氮杂三环[4.2.1.0]壬烷-7-乙酸乙酯和7-苄基-7-氮杂双环[ 2.2.1]庚烷-1-乙酸乙酯E
3. Asymmetric total synthesis of (+)-apovincamine and a formal synthesis of (+)-vincamine. Demonstration of a practical "asymmetric linkage" between aromatic carboxylic acids and chiral acyclic substrates [J] . Arthur G.Schultz, William P.Malachowski, You Pan The Journal of Organic Chemistry . 1997,第5期

机译：（+）-apovincamine的不对称全合成和（+）-vincamine的形式合成。证明了芳香族羧酸与手性无环底物之间的实际“不对称连接”
4. Multistep Microwave-Assisted Solvent-Free Organic Reactions: Synthesis of 1,6-Disubstituted-4-Oxo-1,4-Dihydro-Pyridine-3-Carboxylic Acid Benzyl Esters [C] . Mauro Panunzio, Maria Antonietta Lentini, Eileen Campana, International Conference on Microwave and High Frequency Heating . 2006

机译：多步微波辅助溶剂有机反应：1,6-二取代-4-氧代-1,4-二氢 - 吡啶-3-羧酸苄基酯的合成
5. Asymmetric synthesis of acetamido boronic acids and asymmetric synthesis using boronic esters. [D] . Michnick, Thomas John, II. 1990

机译：乙酰胺基硼酸的不对称合成和使用硼酸酯的不对称合成。
6. Chiral N-Phosphonyl Imine Chemistry: Asymmetric Additions of Ester Enolates for the Synthesis of β-Amino Acids [O] . Jianlin Han, Teng Ai, Thao Nguyen, -1

机译：手性N-膦酰基亚胺化学：酯烯醇盐的不对称加成用于合成β-氨基酸
7. Enantioselective synthesis of chiral phosphonylated 2,3-dihydrofurans by copper catalyzed asymmetric formal 3+2 cycloaddition of propargylic esters with β-keto phosphonates [O] . Xiushuai Chen, Chuanjin Hou, Qing Li, 2016

机译：用β-酮膦酸酯的铜催化的不对称正式3 + 2环加成对手性膦化的2,3-二氢呋喃的映选择性合成β-酮膦酸酯

Asymmetric synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester: Formal synthesis of ramipril

摘要

著录项

相似文献

相关主题

期刊订阅