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Electrochemical oxidation of luteolin at a glassy carbon electrode and its application in pharmaceutical analysis

机译:木犀草素在玻碳电极上的电化学氧化及其在药物分析中的应用

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摘要

Luteolin is a flavonoid reported to occur widely in many medicinal plants. The electrochemical behavior of luteolin was studied in phosphate buffer solution (PBS) of pH 4.0 at a glassy carbon electrode (GCE) by cyclic voltammetry (CV) and differential pulse voltammetric method (DPV). The results indicated the well-defined redox peak of luteolin which was involving two electrons and two protons was observed and the electrode process is adsorption-controlled. The charge transfer coefficient (alpha) was calculated as 0.66. The relationship between oxidation peak current and concentration of luteolin are linear in the range of 1.0x10(-8)-1.0x10(-6)M by DPV method. The detection limit had been estimated as 5.0x10(-9)M. The facile and rapid method has been successfully applied to the detection of luteolin in tablets.
机译:木犀草素是一种黄酮类化合物,据报道在许多药用植物中广泛存在。通过循环伏安法(CV)和微分脉冲伏安法(DPV)研究了木犀草素在pH 4.0的磷酸盐缓冲溶液(PBS)中在玻碳电极(GCE)上的电化学行为。结果表明,观察到了木犀草素的明确的氧化还原峰,该峰涉及两个电子和两个质子,并且电极过程是吸附控制的。电荷转移系数α被计算为0.66。 DPV法测得的氧化峰值电流与木犀草素浓度的关系在1.0x10(-8)-1.0x10(-6)M范围内呈线性关系。检出限估计为5.0x10(-9)M。简便,快速的方法已成功应用于片剂中木犀草素的检测。

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