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Thiol switches in mitochondria: operation and physiological relevance

机译:线粒体中的硫醇转换:操作和生理相关性

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Mitochondria are a major source of reactive - oxygen species (ROS) in the cell, particularly of superoxide and hydrogen peroxide. A number of dedicated enzymes regulate the conversion and consumption of superoxide and hydrogen peroxide in the intermembrane space and the matrix of mitochondria. Nevertheless, hydrogen peroxide can also interact with many other mitochondrial enzymes, particularly those with reactive cysteine residues, modulating their reactivity in accordance with changes in redox conditions. In this review we will describe the general redox systems in mitochondria of animals, fungi and plants and discuss potential target proteins that were proposed to contain regulatory thiol switches.
机译:线粒体是细胞中活性氧(ROS)的主要来源,特别是超氧化物和过氧化氢。许多专门的酶调节膜空间和线粒体基质中超氧化物和过氧化氢的转化和消耗。然而,过氧化氢还可以与许多其他线粒体酶,特别是具有反应性半胱氨酸残基的线粒体酶相互作用,根据氧化还原条件的变化调节其反应性。在这篇综述中,我们将描述动物,真菌和植物线粒体中的一般氧化还原系统,并讨论拟议中包含调节硫醇开关的潜在靶蛋白。

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