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Advances in Biomedical Imaging, Bioengineering, and Related Technologies for the Development of Biomarkers of Pancreatic Disease Summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering Workshop

机译:国立糖尿病,消化,肾脏疾病研究所和国立生物医学影像与生物工程研究所的摘要:胰腺疾病生物标记物的生物医学成像,生物工程及相关技术的进展

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摘要

A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Biomedical Imaging and Bioengineering focused on research gaps and opportunities in the development of new biomarkers of pancreatic disease. The session was held on July 22, 2015, and structured into 6 sessions: 1) Introduction and Overview; 2) Keynote Address; 3) New Approaches to the Diagnosis of Chronic Pancreatitis; 4) Biomarkers of Pain and Inflammation; 5) New Approaches to the Detection of Pancreatic Cancer; and 6) Shed Exosomes, Shed Cells, and Shed Proteins. Recent advances in the fields of pancreatic imaging, functional markers of pancreatic disease, proteomics, molecular and cellular imaging, and detection of circulating cancer cells and exosomes were reviewed. Knowledge gaps and research needs were highlighted. The development of new methods for the noninvasive determination of pancreatic pathology; the use of cellular markers of pancreatic function, inflammation, pain, and malignancy; and the refinement of methods to identify cells and cellular constituents of pancreatic cancer were discussed. The further refinement of sophisticated technical methods and the need for clinical studies to validate these new approaches in large-scale studies of patients at risk for the development of pancreatic disease were repeatedly emphasized.
机译:由国家糖尿病,消化与肾脏疾病研究所和国家生物医学成像与生物工程研究所主办的研讨会着重研究了在开发新的胰腺疾病生物标志物方面的研究空白和机遇。本次会议于2015年7月22日举行,分为6场会议:1)简介和概述; 2)主题演讲; 3)诊断慢性胰腺炎的新方法; 4)疼痛和炎症的生物标志物; 5)检测胰腺癌的新方法; 6)棚外泌体,棚细胞和棚蛋白。回顾了胰腺成像,胰腺疾病的功能标志物,蛋白质组学,分子和细胞成像以及循环癌细胞和外泌体的检测领域的最新进展。强调了知识差距和研究需求。无创测定胰腺病理学新方法的开发;使用胰腺功能,炎症,疼痛和恶性肿瘤的细胞标志物;并讨论了鉴定胰腺癌细胞和细胞成分的方法的改进。反复强调了复杂技术方法的进一步完善以及需要进行临床研究以验证这些新方法在大规模研究中有可能发展为胰腺疾病的风险患者。

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