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首页> 外文期刊>Pancreas >Arterial gastroduodenal infusion of cholecystokinin-33 stimulates the exocrine pancreatic enzyme release via an enteropancreatic reflex, without affecting the endocrine insulin secretion in pigs.
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Arterial gastroduodenal infusion of cholecystokinin-33 stimulates the exocrine pancreatic enzyme release via an enteropancreatic reflex, without affecting the endocrine insulin secretion in pigs.

机译：动脉十二指肠灌注胆囊收缩素-33可通过肠胰反射刺激外分泌胰腺酶释放，而不会影响猪的内分泌胰岛素分泌。

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摘要

OBJECTIVES: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmol kg 10 min) was infused locally to the gastroduodenal artery, or systemically via the jugular vein. Also, a low CCK-33 dose (13 pmol kg) was injected to the duodenum/antrum area before and after a bilateral truncal vagotomy. RESULTS: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min increased protein and trypsin outputs after local infusion to the antral-duodenal area, whereas it had no effect after systemic infusion. Cholecystokinin-33 in the pharmacological dose range 64 to 130 pmol kg 10 min further increased the secretion after both local and systemic infusions. Only CCK-33 infusionsin the pharmacological dose range were able to elevate the plasma insulin levels. Vagotomy had no effect on CCK-33-mediated stimulation of the enzyme release, whereas it had a significant effect on the plasma insulin level. CONCLUSIONS: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min stimulates the enzyme secretion but had no effect on the insulin release via a short enteropancreatic pathway in pigs.
机译：目的：依赖胆囊收缩素（CCK）的外分泌胰腺调节似乎涉及不同物种的不同途径。目的是探讨肠胰反射在CCK介导的外分泌胰腺调节中的作用，并评估该反射在内分泌胰岛素释放中的可能作用。方法：在麻醉的猪中，以递增剂量（4-130 pmol kg 10分钟）的剂量将CCK-33局部注入胃十二指肠动脉，或通过颈静脉全身注入。同样，在双侧截肢迷走神经切断术前后，将低剂量的CCK-33剂量（13 pmol kg）注射到十二指肠/胃窦区域。结果：胆囊收缩素-33的生理剂量范围为4至32 pmol kg，在局部输注到十二指肠区域后10分钟，蛋白质和胰蛋白酶输出增加，而在全身输注后无作用。药理学剂量范围内的胆囊收缩素-33在10分钟后进一步增加了局部和全身输注后的分泌，其剂量范围为64至130 pmol kg。只有在药理学剂量范围内的CCK-33输注能够提高血浆胰岛素水平。迷走神经切断术对CCK-33介导的酶释放刺激没有影响，而对血浆胰岛素水平却有显着影响。结论：胆囊收缩素-33在4至32 pmol kg的生理剂量范围内能在10分钟内刺激酶的分泌，但对猪通过短肠胰腺途径的胰岛素释放没有影响。

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