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首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Are there prognostic factors related to recurrence in pancreatic endocrine tumors?
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Are there prognostic factors related to recurrence in pancreatic endocrine tumors?

机译：胰腺内分泌肿瘤是否有与复发相关的预后因素？

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摘要

AIMS: The aim of this study was to evaluate the rate, site, time of recurrence and prognostic factors related to the appearance of recurrences in patients affected by pancreatic endocrine tumors (PETs). METHODS: Data from 67 consecutive patients with PETs who underwent R0 resection were analyzed. The prognostic factors considered were: gender, age, type of tumor, presence of symptoms, size of tumor, tumor node metastasis (TNM) stage, WHO classification and adjuvant therapy. Results: The recurrence rate was 24.6%, with a mean time of 7.3 +/- 4.5 years. The majority were in the liver (75% of cases) and were rarely local (25%). Univariate analysis of the prognostic factors showed that the risk of recurrences is significantly higher in PETs in MEN-1 syndrome, in tumor size > or =4 cm, in the presence of liver metastases, in TNM stages III-IV and, finally, in PD-Cas and WD-Cas. Multivariate Cox regression analysis showed that only MEN-1 syndrome and the WHO classification were independent predictors of an increased risk of recurrence. CONCLUSIONS: Several prognostic factors were related to recurrences in PETs. MEN-1 syndrome and the WHO classification can be considered independent factors of an increased risk of recurrence. and IAP.
机译：目的：本研究的目的是评估受胰腺内分泌肿瘤（PET）影响的患者的复发率，部位，复发时间和与复发外观相关的预后因素。方法：分析连续67例行R0切除术的PET患者的数据。考虑的预后因素包括：性别，年龄，肿瘤类型，症状的存在，肿瘤的大小，肿瘤淋巴结转移（TNM）阶段，WHO分类和辅助治疗。结果：复发率为24.6％，平均时间为7.3 +/- 4.5年。多数在肝脏中（占病例的75％），很少在局部（占25％）。对预后因素的单因素分析表明，MEN-1综合征的PET，肿瘤大小>或= 4 cm，存在肝转移，TNM的III-IV期以及最后的PET复发风险更高。 PD-Cas和WD-Cas。多元Cox回归分析显示，只有MEN-1综合征和WHO分类是复发风险增加的独立预测因子。结论：几个预后因素与PETs的复发有关。 MEN-1综合征和WHO分类被认为是复发风险增加的独立因素。和IAP。

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