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首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Chronic pancreatitis-like changes detected by endoscopic ultrasound in subjects without signs of pancreatic disease: do these indicate age-related changes, effects of xenobiotics, or early chronic pancreatitis?
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Chronic pancreatitis-like changes detected by endoscopic ultrasound in subjects without signs of pancreatic disease: do these indicate age-related changes, effects of xenobiotics, or early chronic pancreatitis?

机译：在没有胰腺疾病迹象的情况下，通过内窥镜超声检查发现的慢性胰腺炎样变化：这些是否表明与年龄有关的变化，异生物素的作用或早期慢性胰腺炎？

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BACKGROUND/AIMS: The threshold number of endoscopic ultrasound (EUS) criteria for diagnosing chronic pancreatitis (CP) is variable. The presence of more than three abnormal ductular or parenchymal features is typically used, but the diagnostic significance of fewer EUS criteria is currently unclear. The aim of this study was to determine the prevalence of EUS features of CP in patients without pancreaticobiliary disease and to analyze the association with specific factors of interest. METHODS: Over a 24-month period, 2,614 patients underwent EUS for an indication unrelated to pancreaticobiliary disease. Main outcome measurements wereunivariate and multivariate analysis between any EUS abnormality and demographic data and habits. RESULTS: 82 patients (16.8%) showed at least one ductular or parenchymal abnormality. 38 patients presented with only one abnormal feature, 26 patients with two, 12 patients with three, 4 patients with four, and 2 patients with five. Low-level alcohol consumption significantly increased the risk of hyperechoic parenchymal foci, main pancreatic duct (MPD) dilatation and wall hyperechogenicity. Smoking was associated with an increased risk of hyperechoic parenchymal foci. Male gender and advanced age were significantly associated with an increased risk of MPD dilatation. CONCLUSIONS: Long-term smoking and alcohol consumption, although at a low dose, induces CP-like changes. These abnormalities might represent either a clinically silent CP or a toxic effect of smoking and alcohol. Conversely, MPD dilation might represent a normal age-related variant or, alternatively, an effect of chronic low-level alcohol consumption. and IAP.
机译：背景/目的：用于诊断慢性胰腺炎（CP）的内窥镜超声（EUS）标准的阈值数是可变的。通常使用三个以上的异常导管或实质特征，但是目前尚不清楚较少的EUS标准的诊断意义。这项研究的目的是确定无胰胆管疾病的患者中CP的EUS特征的患病率，并分析与特定关注因素的关联。方法：在24个月的时间内，对2,614例患者进行了EUS检查，该指征与胰腺胆道疾病无关。主要结局指标是EUS异常与人口统计学数据和习惯之间的单因素和多因素分析。结果：82例患者（16.8％）表现出至少一种导管或实质异常。 38例患者仅表现出一种异常特征，26例患者表现为两个，12例患者表现为三个，4例患者表现为四个，2例患者表现为五个。少量饮酒会显着增加高回声实质灶，主胰管扩张和壁超回声的风险。吸烟与高回声实质灶的风险增加有关。男性和高龄与MPD扩张风险增加显着相关。结论：长期吸烟和饮酒虽然剂量较低，但会引起CP样变化。这些异常可能代表临床上无声的CP或吸烟和酗酒的毒性作用。相反，MPD扩张可能代表正常的与年龄相关的变异，也可能代表慢性低度饮酒的影响。和IAP。

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