Progress in coenzyme NADH model compounds and asymmetric reduction of benzoylformate

Wang NX; Zhao J

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Progress in coenzyme NADH model compounds and asymmetric reduction of benzoylformate

机译：辅酶NADH模型化合物的研究进展及苯甲酰甲酸酯的不对称还原

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Nicotinamide adenine dinucleotide hydrogen (NADH) could play an important role in living systems and this has stimulated a great deal of interest in the fields of bioorganic and organic chemistry. A large number of NADH model compounds have been developed for studying stercoselective reduction. Herein, the factors involved in stereoselective reduction using NADH model compounds are discussed and the progress of research on coenzyme NADH model compounds is summarized. 1 Introduction 2 Factors of Stereoselective Reduction Using NADH Models 2.1 Effect of a Remote Sterically Demanding Side Chain 2.2 Effect of a Substituent at C-4 of the Dihydropyridine Ring 2.3 Effect of a Special Conformation 3 Conclusion.

机译：烟酰胺腺嘌呤二核苷酸氢（NADH）在生命系统中可能起重要作用，这激发了人们对生物有机化学和有机化学领域的极大兴趣。已经开发出大量的NADH模型化合物用于研究立体选择性还原。在此，讨论了使用NADH模型化合物进行立体选择性还原的因素，并概述了辅酶NADH模型化合物的研究进展。 1简介2使用NADH模型进行立体选择性还原的因素2.1远端立体要求侧链的作用2.2二氢吡啶环C-4处取代基的作用2.3特殊构型的作用3结论。

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《Synlett》 |2007年第18期|共7页
作者
Wang NX; Zhao J;
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正文语种 eng
中图分类有机化学;
关键词
nicotinamide adenine dinucleotide hydrogen; NADH; coenzyme; stereoselectivity; reduction; HIGHLY ENANTIOSELECTIVE REDUCTION; CHIRAL 1; 4-DIHYDROPYRIDINES; HYDRIDE TRANSFER; SERIES; DESIGN; MIMICS; (S-S)-3-(P-TOLYLSULFINYL)-1; 4-DIHYDROPYRIDINES; 1; 4-DIHYDRONICOTINAMIDE; STEREOCONTROL; FEATURES;

机译：烟酰胺腺嘌呤二核苷酸氢;NADH;辅酶;立体选择性;还原;强对映体选择性还原;手性1;4-二氢吡啶;氢化物转移;系列;设计;模拟物;（SS）-3-（P-甲苯磺酰基）-1;4-二氢吡啶;1;4-二氢异烟酰胺;立体控制;特性;

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专利

1. Progress in coenzyme NADH model compounds and asymmetric reduction of benzoylformate [J] . Wang NX, Zhao J Synlett . 2007,第18期

机译：辅酶NADH模型化合物的研究进展及苯甲酰甲酸酯的不对称还原
2. NAD(P)+-NAD(P)H MODELS .85. THE ENZYME/COENZYME/METAL/SUBSTRATE QUATERNARY COMPLEX GENERATED IN THE TRANSITION STATE OF THE REDUCTION OF BENZOYLFORMATE WITH NAD(P)H MODELS [J] . Mikata Y., Ikehara K., Mizukami K. Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1995,第36期

机译：NAD（P）+-NAD（P）H模型.85。在NAD（P）H模型还原苯甲酸酯反应的过渡态中生成的酶/辅酶/金属/基质四元络合物
3. Mechanistic Insights on the Magnesium(II) Ion-Activated Reduction of Methyl Benzoylformate with Chelated NADH Peptide β-Lactam Models [J] . Jesus M.Aizpurua, Claudio Palomo, Raluca M.Fratila, The Journal of Organic Chemistry . 2009,第17期

机译：螯合的NADH肽β-内酰胺模型对镁（II）离子活化的苯甲酰甲酸甲酯还原反应的机理研究
4. Asymmetric Reduction of 2-Bromo-1-phenylethylidenemalononitrile with Chiral NADH Models: Substituent Effect on Enantioselectivity [C] . Jing Li International symposium for Chinese organic chemists . 2000

机译：2-溴-1-苯基乙基甲酰氨腈的不对称还原，具有手性纳米模型：取代基对映选择性的影响
5. I. Development of the in situ reductive ozonolysis of alkenes with tertiary amine N-oxides. II. Progress toward the asymmetric synthesis of peroxyplakoric acid A3. [D] . Schwartz, Christopher P. 2010

机译：I.用叔胺N-氧化物对烯烃进行原位还原臭氧分解的研究。二。过氧苯甲酸A3的不对称合成研究进展。
6. A New Type of NADH Model Compound: Synthesis and Enantioselective Reduction of Benzoylformates to the Corresponding Mandelates [O] . Jia Zhao, Nai-Xing Wang, Wu-Wei Wang, 2007

机译：新型NADH模型化合物：苯甲酰甲酸酯的合成和对映选择性还原成对应的扁桃酸盐
7. A New Type of NADH Model Compound: Synthesis and Enantioselective Reduction of Benzoylformates to the Corresponding Mandelates [O] . Jia Zhao, Nai-Xing Wang, Wu-Wei Wang, 2007

机译：新型NADH模型化合物：苯甲酰甲酸酯的合成和对映选择性还原成对应的扁桃酸盐

Progress in coenzyme NADH model compounds and asymmetric reduction of benzoylformate

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