Biophotonics and biotechnology in pancreatic cancer: cyclic RGD-peptide-conjugated type II quantum dots for in vivo imaging.

Yong KT

首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Biophotonics and biotechnology in pancreatic cancer: cyclic RGD-peptide-conjugated type II quantum dots for in vivo imaging.

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Biophotonics and biotechnology in pancreatic cancer: cyclic RGD-peptide-conjugated type II quantum dots for in vivo imaging.

机译：胰腺癌中的生物光子学和生物技术：用于体内成像的环状RGD-肽共轭II型量子点。

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This work introduces a novel, facile and straightforward approach to produce cyclic-RGD-peptide-conjugated type II CdTe/CdS quantum dot (QD) formulation for pancreatic tumor targeting and imaging in live animals. The ultra-small QDs were prepared by a hot colloidal synthesis method. Phospholipid micelles were then used to encapsulate the QDs, allowing them to be stably dispersed in biological fluids and able to conjugate with cyclic-RGD peptides. The QD complex had shown low cytotoxicity on Panc-1 human pancreatic cancer cell lines. In addition, the tissue sections and biodistribution of QD complexes were imaged and analyzed in mice bearing pancreatic tumor xenografts, confirming specific tumor targeting. These studies support further evaluation of type II QDs as potential probes for early pancreatic cancer assessment and detection.

机译：这项工作介绍了一种新颖，简便，简便的方法来生产环状RGD肽缀合的II型CdTe / CdS量子点（QD）制剂，用于在活体动物中靶向胰腺肿瘤和成像。超小量子点通过热胶体合成法制备。然后使用磷脂微团包封量子点，使它们能够稳定地分散在生物流体中并能够与环状RGD肽结合。 QD复合物对Panc-1人胰腺癌细胞系显示出低细胞毒性。此外，在携带胰腺肿瘤异种移植物的小鼠中对QD复合物的组织切片和生物分布进行了成像和分析，确认了特异性肿瘤靶向。这些研究支持进一步评估II型QD作为早期胰腺癌评估和检测的潜在探针。

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《Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.]》 |2010年第5期|共12页
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Yong KT;
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中图分类消化系及腹部疾病;
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1. Biophotonics and biotechnology in pancreatic cancer: cyclic RGD-peptide-conjugated type II quantum dots for in vivo imaging. [J] . Yong KT Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] . 2010,第5期

机译：胰腺癌中的生物光子学和生物技术：用于体内成像的环状RGD-肽共轭II型量子点。
2. Superior photodynamic effect of carbon quantum dots through both type I and type II pathways: Detailed comparison study of top-down-synthesized and bottom-up-synthesized carbon quantum dots [J] . Pillar-Little Timothy J., Wanninayake Namal, Nease Leona, Carbon: An International Journal Sponsored by the American Carbon Society . 2018,第期

机译：碳量子点通过I型和II型途径的卓越光动力学效应：上下合成和底层合成的碳量子点的详细比较研究
3. Tuning Between Quantum-Dot- and Quantum-Well-Like Behaviors in Type II ZnTe Submonolayer Quantum Dots by Controlling Tellurium Flux During MBE Growth [J] . H. JI, B. ROY, S. DHOMKAR, Journal of Electronic Materials . 2013,第11期

机译：在MBE生长过程中通过控制碲通量来调节II型ZnTe亚单层量子点中的量子点和量子阱相似行为
4. Selective functionalization of II-VI semiconductor quantum dots with peptides and integrins of cancer cells for biophotonic applications [C] . Bakhysh Bairamov, Vladimir Toporov, Farid Bayramov, Conference on Bioengineered and Bioinspired Systems . 2007

机译：二维半导体量子点用肽和癌细胞整合的生物光学应用选择性官能化
5. Self-assembled quantum dots: A theoretical study of the exciton in single and vertically coupled type-II quantum dots. [D] . Janssens, Karen. 2003

机译：自组装量子点：对单个和垂直耦合的II型量子点中激子的理论研究。
6. Quantum Dots for Biophotonics [O] . Ken-Tye Yong 2012

机译：生物光子学的量子点
7. Table 5.5.a.1 Tumor size and treatment (rate of resectability) Figure 5.5.a.2 Cumulative survival of the patients after pancreatectomy for TS1 cancer according to residual tumors Figure 5.5.a.3 Cumulative survival of the patients with TS1 cancer according to extent of lymph node dissection Figure 5.5.a.4 Combined resection of portal vein and cumulative survival of the patients after pancreatectomy for TS1 cancer of UICC Stage IIa or IIb in the pancreatic head Figure 5.5.a.5 Combined resection of peripancreatic plexus and cumulative survival of the patients after pancreatectomy for TS1 cancer of UICC Stage IIa or IIb in the pancreatic head Figure 5.5.a.6 Combined resection of peripancreatic plexus when there is no plexus infiltration and cumulative survival of the patients after pancreatectomy for TS1 cancer of UICC Stage IIa or IIb in the pancreatic head Figure 5.5.a.7 Combined resection of artery and cumulative survival of the patients after pancreatectomy for TS1 cancer of UICC Stage IIa or IIb in the pancreatic head Figure 5.5.a.8 Combined resection of portal vein and cumulative survival of the patients after pancreatectomy for TS2 (2.1-4.0 cm) cancer of UICC Stage IIa or IIb in the pancreatic head Figure 5.5.a.9 Combined resection of peripancreatic plexus and cumulative survival of the patients after pancreatectomy for TS2 (2.1-4.0 cm) cancer of UICC Stage IIa or IIb in the pancreatic head [O] . 2007

机译：表5.5.a.1肿瘤大小和治疗（重新切性率）图5.5.a.2根据残留肿瘤对TS1癌胰腺切除后患者的累积存活图5.5.A.3累积存活根据淋巴结解剖的程度，TS1癌症的患者图5.5.A.4在胰头胰腺IIA或IIB癌症术后胰岛切除术后的门静脉和累积患者的累积存活图5.5。 A.5在胰头术后IIA或IIB胰腺切除术后，患者胰腺癌丛和患者累积存活的组合图5.5.A.6当没有丛浸润时，围裙丛生的围嘴巴丛的切除胰腺切除术后胰腺切除术后胰腺炎癌症的累积存活图5.5.A.7在TS1癌症胰腺切除后患者的动脉和累积存活的组合UICC阶段IIA或IIB在胰头图5.5.A.8在胰头胰腺阶段IIA或IIB癌症的胰腺切除后，患者的门静脉和累积患者的累积存活率图5.5.A.9在胰头胰腺阶段IIA或IIB的胰腺切除术后胰腺切除术后患者患者患者患者的累积生存的组合和胰腺头

Biophotonics and biotechnology in pancreatic cancer: cyclic RGD-peptide-conjugated type II quantum dots for in vivo imaging.

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