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首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Alterations of systemic endotoxemia over the course of acute edematous pancreatitis. correlation to the advent of an infection?
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Alterations of systemic endotoxemia over the course of acute edematous pancreatitis. correlation to the advent of an infection?

机译：在急性水肿性胰腺炎过程中全身内毒素血症的改变。与感染的发生有关？

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摘要

BACKGROUND/AIMS: To define whether bacterial translocation occurs over the course of acute edematous pancreatitis and to correlate its presence to the advent of an infection since data in humans are lacking. METHODS: Thirty-three patients hospitalized over the period January 2000-January 2001 were subjected to venipuncture at regular time intervals for the collection of blood samples for blood culture and for determination of endotoxins and of C-reactive protein. Endotoxins were measured by the Limulus assay and C-reactive protein by nephelometry. RESULTS: A wide range of concentrations of endotoxins was observed over the first 3 days of the disease. Mean (+/-SE) of endotoxins was 4.01 +/- 1.36 and 2.42 +/- 0.95 EU/ml 3 and 6 h, respectively, after admission of afebrile patients. Respective values 3 and 6 h after admission of febrile patients were 3.03 +/- 1.14 and 5.84 +/- 2.28 EU/ml (normal <0.1 EU/ml); these values gradually decreased after the second day. No correlation was found between endotoxinsand C-reactive protein. Endotoxins were increased as a result of the occurrence of an infection on the third day. CONCLUSIONS: A significant level of endotoxemia is observed over the course of acute edematous pancreatitis, which might be correlated to the advent of the systemic inflammatory response.
机译：背景/目的：定义细菌是否在急性水肿性胰腺炎的过程中发生移位，并将其存在与感染的发生相关联，因为缺乏人类数据。方法：2000年1月至2001年1月住院的33例患者，定期接受静脉穿刺术，以收集血液样本进行血液培养，并测定内毒素和C反应蛋白。通过the测定法测定内毒素，通过浊度法测定C反应蛋白。结果：在疾病的前三天内观察到多种浓度的内毒素。入院治疗后3小时和6小时，内毒素的平均（+/- SE）分别为4.01 +/- 1.36和2.42 +/- 0.95 EU / ml EU / ml。入院后3小时和6小时分别为3.03 +/- 1.14和5.84 +/- 2.28 EU / ml（正常<0.1 EU / ml）;这些值在第二天后逐渐降低。内毒素与C反应蛋白之间没有相关性。由于感染的第三天，内毒素增加了。结论：在急性水肿性胰腺炎的过程中观察到明显的内毒素血症水平，这可能与全身炎症反应的出现有关。

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