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首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Long-term survival and prognostic indicators in small (
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Long-term survival and prognostic indicators in small (

机译：小型（<或= 2 cm）胰腺癌的长期生存和预后指标。

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OBJECTIVES: In a matched analysis, we investigated clinical, histopathological, and survival characteristics of small (2 cm. Two experienced pathologists, who were blinded to survival data, independently reviewed tumor stage and differentiation. Kaplan-Meier survival analysis and Cox proportional hazards models were applied for data analyses. RESULTS: In patients with localized disease (stages I and II), survival was similar in small and large PaC but survival was significantly better in small PaC with regional nodal metastasis (stage III) as compared to similar stage large PaC (5-year survival 44 vs. 7%, median survival 58 vs.18 months, p < 0.001). Well-differentiated small and large PaC had similar median survival (76 vs. 74 months, p = NS). In multivariate analysis, tumor differentiation, not tumor size, was the only independent factor predicting survival in PaC (risk ratio, RR, for moderate vs. well- differentiated: 2.6, 95% confidence interval, CI, 1.5-4.5, and RR for poorly differentiated vs. well-differentiated: 5.0, 95% CI 2.4-10.1). CONCLUSION: Tumor differentiation may be a better predictor of survival in resectable PaC than tumor stage.
机译：目的：在一项匹配分析中，我们调查了小（<或= 2 cm）胰腺癌（PaC）与大PaC相比的临床，组织病理学和生存特征。方法：从梅奥病理数据库中，我们确定了41例连续的小PaC患者和94例边缘阴性PaC> 2 cm的匹配对照。两名不愿了解生存数据的经验丰富的病理学家独立审查了肿瘤的阶段和分化。将Kaplan-Meier生存分析和Cox比例风险模型用于数据分析。结果：在局部疾病患者（I和II期）中，小PaC和大PaC的生存率相似，但是具有局部淋巴结转移的小PaC的生存率（III期）明显优于相似阶段的大PaC（5年生存率） 44 vs. 7％，中位生存期58 vs. 18个月，p <0.001）。高分化的小和大PaC的中位生存期相似（76个月与74个月，p = NS）。在多变量分析中，肿瘤分化而不是肿瘤大小是预测PaC生存率的唯一独立因素（中度与高分化的风险比，RR：2.6、95％置信区间，CI，1.5-4.5和RR）低分化与高分化：5.0，95％CI 2.4-10.1）。结论：在可切除的PaC中，肿瘤分化可能比肿瘤分期更好地预测生存。

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