...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological chemistry >Some of the early events underlying Th2 cell maturation and susceptibility to Leishmania major infection in BALB/c mice.
【24h】

Some of the early events underlying Th2 cell maturation and susceptibility to Leishmania major infection in BALB/c mice.

机译：BALB / c小鼠中Th2细胞成熟和对利什曼原虫主要感染易感性的一些早期事件。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The first experimental evidence for the development of polarized CD4+ Th1 and Th2 responses in vivo has been obtained using the murine model of infection with Leishmania major, an intracellular parasite of macrophages in their vertebrate host. Genetically determined resistance and susceptibility to infection with this parasite have been clearly demonstrated to result from the development of polarized Th1 and Th2 responses, respectively. Using this model system, the dominant role of cytokines in the induction of polarized CD4+ responses has been validated in vivo. The requisite role of IL-4 in mediating both Th2 differentiation and susceptibility to infection in BALB/c mice has directed interest towards the search for evidence of IL-4 production early after infection and identification of its cellular source. We have been able to demonstrate a burst of IL-4 production in susceptible BALB/c mice within the first day of infection with L. major and could establish that this rapidly produced IL-4 instructed Th2 lineage commitment of subsequently activated CD4+ T cells and stabilized this commitment by downregulating IL-12 Rbeta2 chain expression, resulting in susceptibility to infection. Strikingly, this early IL-4 response to infection resulted from the cognate recognition of a single epitope in a distinctive antigen, LACK, from this complex microorganism by a restricted population of CD4+ T cells that express Vbeta4-Valpha8 T cell receptors.
机译：使用利什曼原虫感染的小鼠模型获得了体内极化的CD4 + Th1和Th2反应发展的第一个实验证据，利什曼原虫是脊椎动物宿主中巨噬细胞的细胞内寄生虫。遗传学确定的抵抗力和对这种寄生虫感染的敏感性已明确证明分别来自极化的Th1和Th2反应的发展。使用该模型系统，已经在体内验证了细胞因子在极化CD4 +反应诱导中的主导作用。 IL-4在介导BALB / c小鼠Th2分化和感染易感性中的必需作用已引起人们的兴趣，即在感染后早期寻找IL-4产生的证据并鉴定其细胞来源。我们已经能够证明在感染大麦芽孢杆菌的第一天，易感的BALB / c小鼠爆发了IL-4的产生，并且可以证明这种迅速产生的IL-4指示了随后激活的CD4 + T细胞和Th2细胞的Th2谱系定型。通过下调IL-12 Rbeta2链表达来稳定这一承诺，从而导致对感染的易感性。令人惊讶的是，对感染的这种早期IL-4响应是由表达Vbeta4-Valpha8 T细胞受体的CD4 + T细胞的有限种群对该复杂微生物对独特抗原LACK中单个表位的同源识别所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号