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首页> 外文期刊>Pain. >How diagnostic tests help to disentangle the mechanisms underlying neuropathic pain symptoms in painful neuropathies
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How diagnostic tests help to disentangle the mechanisms underlying neuropathic pain symptoms in painful neuropathies

机译：诊断测试如何帮助弄清疼痛性神经病中神经性疼痛症状的潜在机制

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Neuropathic pain, ie, pain arising directly from a lesion or disease affecting the somatosensory afferent pathway, manifests with various symptoms, the commonest being ongoing burning pain, electrical shock-like sensations, and dynamic mechanical allodynia. Reliable insights into the mechanisms underlying neuropathic pain symptoms come from diagnostic tests documenting and quantifying somatosensory afferent pathway damage in patients with painful neuropathies. Neurophysiological investigation and skin biopsy studies suggest that ongoing burning pain primarily reflects spontaneous activity in nociceptive-fiber pathways. Electrical shock-like sensations presumably arise from high-frequency ectopic bursts generated in demyelinated, nonnociceptive, Ab fibers. Although the mechanisms underlying dynamic mechanical allodynia remain debatable, normally innocuous stimuli might cause pain by activating spared and sensitized nociceptive afferents. Extending the mechanistic approach to neuropathic pain symptoms might advance targeted therapy for the individual patient and improve testing for new drugs.
机译：神经性疼痛，即直接由病变或疾病影响躯体感觉传入通路而引起的疼痛，表现为各种症状，最常见的是持续性灼痛，电击样感觉和动态机械性异常性疼痛。对神经性疼痛症状的潜在机制的可靠见解来自诊断测试，该测试记录并定量了疼痛性神经病患者的躯体感觉传入途径损伤。神经生理学研究和皮肤活检研究表明，持续的灼痛主要反映伤害性纤维途径中的自发活动。类似电击的感觉可能是由脱髓鞘的，非伤害感受性的Ab纤维中产生的高频异位猝发引起的。尽管动态机械性异常性疼痛的机制尚有争议，但正常情况下，无害刺激可能会通过激活多余的和敏感的伤害感受传入来引起疼痛。将机制方法扩展到神经性疼痛症状可能会促进针对个别患者的靶向治疗并改善对新药的测试。

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