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首页> 外文期刊>Pain. >Cerebral responses to a continual tonic pain stimulus measured using positron emission tomography.
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Cerebral responses to a continual tonic pain stimulus measured using positron emission tomography.

机译：使用正电子发射断层显像仪测量的大脑对持续性强直疼痛刺激的反应。

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摘要

We have previously demonstrated the localised positron emission tomographic cerebral correlates of the experience of painful phasic heat in the normal human brain. In this study we examine whether these responses are different using a continuous, tonic heat stimulus. The regional cerebral responses to non-painful and painful thermal stimuli in 12 male subjects were studied by monitoring serial measurements of regional cerebral blood flow (rCBF) with positron emission tomography (PET) using H2(15)O. Significantly increased rCBF responses to tonic noxious stimulation compared with non-noxious stimulation were observed bilaterally in the anterior cingulate (Brodmann's area (BA) 24) cortex. Contralateral responses were observed in the lentiform nucleus and posterior insula cortex and ipsilateral responses were observed in the thalamus, cerebellum, prefrontal (BA 10) cortex and anterior insula cortex. These findings demonstrate general agreement between the main areas of cerebral activation during both phasic and tonic pain.
机译：先前我们已经证明了正常人脑中痛苦的相热经历的局部正电子发射断层扫描脑相关性。在这项研究中，我们使用连续的补品热刺激来检查这些反应是否不同。通过使用H2（15）O监测正电子发射断层扫描（PET）的局部脑血流量（rCBF）的连续测量，研究了12位男性受试者对非疼痛和疼痛性热刺激的局部脑反应。与无毒刺激相比，在前扣带回（Brodmann氏区（BA）24）皮层的双侧观察到对无毒刺激的rCBF反应显着增加。对侧反应观察到在大眼状核和后岛鞘皮质，同侧反应观察到丘脑，小脑，前额叶（BA 10）皮质和前岛鞘皮质。这些发现表明，在阶段性和强直性疼痛过程中，大脑激活的主要区域之间普遍达成一致。

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