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首页> 外文期刊>Pain. >Effects of tricyclic antidepressants on mechanosensitive pelvic nerve afferent fibers innervating the rat colon.
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Effects of tricyclic antidepressants on mechanosensitive pelvic nerve afferent fibers innervating the rat colon.

机译：三环类抗抑郁药对支配大鼠结肠的机械敏感性盆腔神经传入纤维的影响。

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The aim of this study was to examine the effects of tricyclic antidepressants on responses of mechanosensitive afferent fibers innervating the rat colon. A total of 53 fibers in the decentralized S1 dorsal root were studied. The effects of the non-specific monoamine reuptake inhibitor imipramine (IMI), the noradrenaline reuptake inhibitor desipramine (DES), and the serotonin reuptake inhibitor clomipramine (CLO) were tested on responses of 22 mechanosensitive afferent fibers to noxious colorectal distension (CRD; 80 mmHg). Cumulative doses of 16 mg/kg of IMI, DES and of CLO reduced responses to noxious CRD to a mean 20%, 22% and 46% of control, respectively. The mean inhibitory doses of the three antidepressants did not differ significantly. Inhibitory effects were independent of potential effects on neurotransmitter reuptake: the effects of IMI and DES were not blocked by the adrenoreceptor antagonist phentolamine, and the effects of IMI and CLO were not affected by the serotonin receptor antagonist metergoline. Attenuation of afferent nerve activity was not mimicked by the anticholinergic glycopyrrolate; the cholinesterase inhibitor neostigmine did not attenuate the effect of IMI on responses to noxious CRD. Interestingly, the opioid receptor antagonist naloxone partially reversed the effects of IMI, and the NMDA receptor channel blocker MK-801 enhanced the inhibitory effects of DES and CLO. These results document that responses of mechanosensitive pelvic nerve afferent fibers to noxious CRD are significantly attenuated by tricyclic antidepressants, a peripheral action that may contribute to the beneficial effects of tricyclic antidepressants in treatment of irritable bowel syndrome.
机译：这项研究的目的是检查三环类抗抑郁药对支配大鼠结肠的机械敏感性传入纤维反应的影响。在分散的S1背根中总共研究了53根纤维。测试了22种机械敏感性传入纤维对有害大肠扩张的反应，测试了非特异性单胺再摄取抑制剂咪咪嗪（IMI），去甲肾上腺素再摄取抑制剂地昔帕明（DES）和血清素再摄取抑制剂氯米帕明（CLO）的作用。毫米汞柱）。 IMI，DES和CLO的累积剂量为16 mg / kg，分别降低了对有害CRD的反应，分别为对照组的20％，22％和46％。三种抗抑郁药的平均抑制剂量没有显着差异。抑制作用独立于对神经递质再摄取的潜在影响：肾上腺素受体拮抗剂苯妥拉明未阻断IMI和DES的作用，而血清素受体拮抗剂美特古琳未影响IMI和CLO的作用。抗胆碱能格隆溴铵不能模仿传入神经活动的减弱。胆碱酯酶抑制剂新斯的明不能减弱IMI对有害CRD的反应。有趣的是，阿片受体拮抗剂纳洛酮部分逆转了IMI的作用，而NMDA受体通道阻滞剂MK-801增强了DES和CLO的抑制作用。这些结果证明，三环抗抑郁药可显着减弱机械敏感的盆腔神经传入纤维对有害CRD的反应，这是一种外围作用，可能有助于三环抗抑郁药治疗肠易激综合征的有益作用。

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