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首页> 外文期刊>Pain. >Temporal and qualitative properties of cold pain and heat pain: a psychophysical study.
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Temporal and qualitative properties of cold pain and heat pain: a psychophysical study.

机译：冷痛和热痛的时间和质量特性：一项心理物理研究。

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摘要

Dorsal horn neurons that respond to noxious cold also respond to noxious heat, suggesting the hypothesis that pain evoked by temperature extremes, whether hot or cold, may be processed similarly in the CNS. In this study, we tested perceptual consequences of this hypothesis by comparing characteristics of heat and cold pain, as well as of innocuous warm and cool. Eight healthy subjects performed psychophysical tasks involving hot and cold cutaneous stimuli. Using a 9-cm2 contact thermode, temperatures from -5 degrees to 48 degrees C were each applied for 30 s to the thenar eminence. Subjects gave continuous ratings of perceived temperature and pain intensity, using an electronic VAS. After each stimulus, subjects also reported the maximum stimulus intensity and unpleasantness, and chose appropriate words from a list of qualitative verbal descriptors. We found that larger temperature differences were needed in the noxious cold than in the noxious heat range to produce equal perceptual differences. Further, in the heat range, stimulus-response functions were steeper for noxious than for innocuous temperatures, whereas in the cold range, the opposite held true. The relative unpleasantness of heat pain did not differ from that of cold pain, but subjects used a wider range of qualitative words to describe cold pain. Perceived stimulus intensity was compared to temperature recordings from intradermal and skin surface thermocouples. Heat pain, cool and warmth appeared to depend on surface temperature, whereas cold pain was related to subcutaneous temperature, suggesting different receptors for noxious heat and noxious cold. These data, combined with results of human brain imaging and primate electrophysiological studies, suggest that the unpleasantness associated with both heat pain and cold pain is processed similarly in the CNS, whereas differential information about stimulus quality is preserved in the cerebral cortex.
机译：对伤害性冷作出反应的背角神经元也对伤害性热作出反应，这表明在中枢神经系统中，温度极限引起的疼痛，无论是热的还是冷的，都可能得到类似的处理。在这项研究中，我们通过比较热痛和冷痛以及无害的冷热痛的特征，测试了该假设的感知结果。八名健康受试者执行了涉及热和冷皮肤刺激的心理物理任务。使用9平方厘米的接触式测温仪，将-5摄氏度至48摄氏度的温度分别施加30 s来达到鱼际隆起。使用电子VAS，受试者对感知的温度和疼痛强度进行了连续评估。每次刺激后，受试者还报告了最大刺激强度和不适感，并从定性语言描述词列表中选择了合适的词。我们发现有毒感冒中需要比有毒热范围更大的温差才能产生相等的感知差异。此外，在热范围内，有毒的刺激响应功能比无害温度下的陡峭，而在寒冷范围内，相反。热痛的相对不愉快与冷痛的不愉快没有区别，但是受试者使用了更多的定性词语来描述冷痛。将感知的刺激强度与皮内和皮肤表面热电偶的温度记录进行比较。热痛，凉爽和温暖似乎取决于表面温度，而冷痛与皮下温度有关，表明有毒的热量和有毒的寒冷的受体不同。这些数据与人脑成像和灵长类动物电生理研究的结果相结合，表明与热痛和冷痛相关的不适在CNS中的处理方式相似，而有关刺激质量的差异信息保留在大脑皮层中。

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