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Evaluation of the pain matrix using EEG source localization: a feasibility study.

机译：使用脑电图源定位评估疼痛矩阵：一项可行性研究。

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OBJECTIVES: An extensive neuroimaging literature on chronic pain demonstrates increased cerebral blood flow and metabolism consistent with increased neuronal activity in the structures comprising the "pain matrix"; furthermore, some of these regions have been shown to encode pain intensity. It is the objective of this study to demonstrate the feasibility of using quantitative electroencephalography (EEG) source localization to reflect and to quantify activity in the pain matrix. METHODS: Eyes closed resting EEG was recorded from 19 standardized scalp locations, in a pilot sample of five patients with chronic neuropathic pain, before and after pain reduction. Quantitative electro encephalography (QEEG) source localization was computed estimating the mathematically most probable source generators of EEG surface potentials in each state. Sources identified in this way have been demonstrated to coregister with those identified by neuroimaging methods. RESULTS: QEEG sources demonstrated frequency specific increased neuronal activity in the baseline high pain state in structures including the thalamus, somatosensory cortex, anterior and posterior insula, medial and lateral prefrontal cortex and cingulate. Significant reduction of activation in these regions was seen when pain was reduced (>/=50% on subjective ratings). CONCLUSION: The areas that were activated in the high pain state localized to the same regions reported by other neuroimaging methods and with frequency specificity. The frequency and regionally specific activation may indicate distinctive patterns of pathophysiology underlying the pain matrix. Although in a small number of patients, this work suggests that QEEG may be a useful tool in the exploration and quantification of the pain matrix in a clinical setting.
机译：目的：关于慢性疼痛的大量神经影像学文献表明，与“疼痛基质”有关的结构中，脑血流量和新陈代谢的增加与神经元活性的增加相一致。此外，这些区域中的一些已经显示出编码疼痛强度。这项研究的目的是证明使用定量脑电图（EEG）源定位来反映和量化疼痛基质中活性的可行性。方法：在减轻疼痛前后的5名慢性神经性疼痛患者的试验样本中，从19个标准化头皮位置记录了闭眼静息EEG。计算定量脑电图（QEEG）的源定位，以估算每种状态下EEG表面电位的数学上最可能的源生成器。已经证明以这种方式识别的来源与通过神经影像学方法识别的来源共配准。结果：QEEG资料显示，在丘脑，躯体感觉皮层，前，后绝缘，前额内侧和外侧皮层和扣带状结构的基线高疼痛状态下，特定频率的神经元活动频率增加。当疼痛减轻时（在主观评分上> / = 50％），可以看到这些区域的激活显着减少。结论：在高疼痛状态下被激活的区域位于其他神经影像学方法报道的频率相同的区域。频率和区域特定的激活可能表明疼痛矩阵背后的病理生理学独特模式。尽管在少数患者中，这项工作表明QEEG可能是在临床环境中探索和量化疼痛矩阵的有用工具。

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