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In vitro activity of the F-6 fraction of oregano against Giardia intestinalis

机译：牛至的F-6组分对肠道贾第鞭毛虫的体外活性

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摘要

Giardiosis is a neglected parasitic disease that produces diarrhoea and different degrees of malabsorption in humans and animals. Its treatment is based on derivatives of 5-nitroimidazoles, benzimidazoles, nitrofuranes, acridine and nitrotiazoles. These drugs produce undesirable secondary effects, ranging from a metallic taste in the mouth to genetic damage and the selection of resistant strains; therefore, it is necessary to develop new therapeutic alternatives. We demonstrated that a 2-h treatment with 2·87 μg ml -1 of fraction 6 of Lippia graveolens (F-6) was sufficient to kill half of an experimental Giardia intestinalis (Syn. G. duodenalis, G. lamblia) population, based on the reduction of MTT-tetrazolium salt levels. F-6 breaks the nuclear envelope and injures the ventral suckling disc. The major compounds of F-6 were characterized as naringenin, thymol, pinocembrin and traces of compounds not yet identified. The results suggest that Lippia is a potential source to obtain compounds with anti-Giardia activity. This knowledge is an important starting point to develop new anti-giardial drugs. Future studies will be required to establish the efficacy of F-6 in vivo using an animal model.
机译：贾第鞭毛虫病是一种被忽视的寄生虫病，会在人和动物中引起腹泻和不同程度的吸收不良。其处理基于5-硝基咪唑，苯并咪唑，硝基呋喃、,啶和硝基噻唑的衍生物。这些药物会产生不良的副作用，从口中的金属味到遗传损伤和耐药菌株的选择，不一而足。因此，有必要开发新的治疗方法。我们证明，用2·87μgml -1的Lippia Gradolens（F-6）第6部分进行2小时处理足以杀死实验性贾第鞭毛虫肠道菌群（S. G. duodenalis，G. lamblia），基于降低MTT-四唑鎓盐水平。 F-6破坏核被膜并伤害腹背乳盘。 F-6的主要化合物的特征是柚皮苷，百里香酚，松皮精和痕量尚未鉴定的化合物。结果表明，Lippia是获得具有抗贾第鞭毛虫活性的化合物的潜在来源。这些知识是开发新的抗疟疾药物的重要起点。使用动物模型需要进一步的研究来确定F-6在体内的功效。

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