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Changes in the small intestine of Schistosoma mansoni-infected mice fed a high-fat diet

机译：饲喂高脂饮食的曼氏血吸虫感染小鼠小肠的变化

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The consumption of a high-fat diet modifies both the morphology of the small intestine and experimentally tested effects of schistosomiasis mansoni. However, whether a schistosomiasis infection associated with a high-fat diet causes injury to the small intestine has never been investigated. Mice were fed either a high-fat or a standard-fat diet for 6 months and were then infected with Schistosoma mansoni cercariae. Physical characteristics of the intestinal tissue (mucosal thickness, small intestinal villi length and height, and abundance of goblet cells and enterocytes on the villous surface) and the distribution of granulomas along the intestinal segments and their developmental stage were measured at the time of sacrifice (9 or 17 weeks post-infection). The group fed a high-fat diet exhibited different granuloma stages, whereas the control group possessed only exudative granulomas. The chronically infected mice fed a high-fat diet exhibited higher granuloma and egg numbers than the acutely infected group. Exudative, exudative/exudative-productive and exudative-productive granulomas were present irrespective of diet. Computer-aided morphometric analysis confirmed that villus length, villus width, muscular height and submucosal height of the duodenal and jejunal segments were affected by diet and infection. In conclusion, a high-fat diet and infection had a significant impact on the small intestine morphology and morphometry among the animals tested.
机译：食用高脂饮食会改变曼氏血吸虫病小肠的形态和经实验测试的效果。然而，从未研究过与高脂饮食有关的血吸虫病感染是否会损害小肠。给小鼠喂高脂或标准脂饮食6个月，然后感染曼氏血吸虫尾c。在处死时，测量肠组织的物理特征（粘膜厚度，小肠绒毛长度和高度，以及绒毛表面上的杯状细胞和肠上皮细胞的丰度）以及肉芽肿沿肠段的分布及其发育阶段（感染后9或17周）。喂养高脂饮食的组表现出不同的肉芽肿阶段，而对照组仅具有渗出性肉芽肿。喂养高脂饮食的慢性感染小鼠比急性感染组的肉芽肿和卵数更高。与饮食无关，存在渗出性，渗出性/渗出性生产性和渗出性肉芽肿。计算机辅助形态计量学分析证实，十二指肠和空肠段的绒毛长度，绒毛宽度，肌肉高度和粘膜下高度受饮食和感染的影响。总之，高脂饮食和感染对所测试动物的小肠形态和形态有重大影响。

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