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首页> 外文期刊>Parasitology >Mode of action of levamisole and pyrantel, anthelmintic resistance, E153 and Q57.
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Mode of action of levamisole and pyrantel, anthelmintic resistance, E153 and Q57.

机译：左旋咪唑和吡喃酮的作用方式，抗驱虫药性，E153和Q57。

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Here we review molecular information related to resistance to the cholinergic anthelmintics in nematodes. The amount of molecular information available varies between the nematode species, with the best understood so far being C. elegans. More information is becoming available for some other parasitic species. The cholinergic anthelmintics act on nematode nicotinic acetylcholine receptors located on somatic muscle cells. Recent findings demonstrate the presence of multiple types of the nicotinic receptors in several nematodes and the numerous genes required to form these multimeric proteins. Not only are the receptors the product of several genes but they are subject to modulation by several other proteins. Mutations altering these modulatory proteins could alter sensitivity to the cholinergic anthelmitics and thus lead to resistance. We also discuss the possibility that resistance to the cholinergic anthelmintics is not necessarily the result of a single mutation but may well be polygenic in nature. Additionally, the mutations resulting in resistance may vary between different species or between resistant isolates of the same species. A list of candidate genes to examine for SNPs is presented.
机译：在这里，我们审查与抗线虫胆碱能驱虫药有关的分子信息。线虫种类之间可用的分子信息量各不相同，到目前为止，最了解的是秀丽隐杆线虫。更多信息可用于其他一些寄生物种。胆碱能驱虫药作用于位于体细胞上的线虫烟碱乙酰胆碱受体。最近的发现表明在几种线虫中存在多种类型的烟碱样受体，以及形成这些多聚体蛋白质所需的众多基因。受体不仅是几种基因的产物，而且还受到其他几种蛋白质的调节。改变这些调节蛋白的突变可能会改变对胆碱能驱虫药的敏感性，从而导致耐药性。我们还讨论了对胆碱能驱虫药的抗药性不一定是单个突变的结果，而实际上可能是多基因的。另外，导致抗性的突变可在不同物种之间或同一物种的抗性分离株之间变化。列出了检查SNP的候选基因列表。

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